Video clip commemorating V Foundation Award.
James Brugarolas, M.D., Ph.D. is an Associate Professor at UT Southwestern Medical Center in the departments of Internal Medicine and Developmental Biology. He is a Virginia Murchison Linthicum Scholar in Medical Research and the leader of the Kidney Cancer Program. Dr. Brugarolas also co-leads the Cell Networks Scientific Program of the Harold C. Simmons Comprehensive Cancer Center.
Dr. Brugarolas received his medical degree from the University of Navarra, Spain (1993), and his Ph.D. from the Massachusetts Institute of Technology (1998). He did an internship and residency in internal medicine at Duke University Medical Center, and subsequently a fellowship in oncology at a combined program of the Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Massachusetts General Hospital. In 2003, he became an instructor at Harvard Medical School.
In 2006, Dr. Brugarolas joined UT Southwestern Medical Center to build an innovative kidney cancer program. The goal of his program is to understand the fundamental biology of renal cancer and create a platform that brings discoveries from the laboratory into the clinic. Highlights of the research program include (i) the discovery that the BAP1 gene is inactivated in 15% of clear cell renal cell carcinomas (ccRCCs), (ii) the establishment of a foundation for the first molecular genetic classification of sporadic ccRCC, (iii) the implication of the TSC1 gene as a tumor suppressor in ccRCC and a putative predictor of responsiveness to mTORC1 inhibitors clinically, (iv) the characterization of a feedback loop that links the two dominant pathways in renal cancer, (v) the identification of a novel effector of mTORC1, (vi) the development of the first animal model of renal cancer that reproduces the treatment responsiveness in patients, and (vii) the determination that mTORC1 inhibitors have activity against epithelioid angiomyolipomas.
Certified in Medical Oncology by the American Board of Internal Medicine, Dr. Brugarolas runs a kidney cancer clinic at the Simmons Comprehensive Cancer Center. Dr. Brugarolas is active in multiple professional associations including the American Society of Clinical Oncology (ASCO) and the American Association for Cancer Research (AACR). He has served on research grant review panels of the National Cancer Institute, National Institutes of Health, Bethesda, MD, and the American Cancer Society, Atlanta, GA. He is a member of the external advisory board and counsels MD Anderson Cancer Center on their Kidney Cancer Specialized Program of Research Excellence application. He was inducted to the American Society for Clinical Investigation in 2013 and is the recipient of multiple awards including the Claudia Adams Barr Award for Innovative Basic Cancer Research, a V Scholar Award, and a Research Scholar Award from the American Cancer Society.