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I joined the faculty of the Department of Psychiatry at UT Soutwestern Medical Center
after receiving my education at Yale University (undergraduate and postdoctoral work)
and the University of California at Irvine (doctoral work). If you want to know more
about where I've been and what I've done, please look at my Publications website or download my CV.
My laboratory's current primary focus is on the neuroplasticity that may underlie or
accompany psychiatric disorders. Specifically, I am interested in how mediators of
neuroplasticity in a developmental context play a role in mediating neuroplasticity in
the adult brain. Inability of the brain to "adapt" may contribute to - or exacerbate -
myriad psychiatric and neurological disorders, such as addiction, depression, or
dementia. One mediator of neuroplasticity that we focus on is adult hippocampal
neurogenesis. We currently study adult hippocampal neurogenesis with a variety of in
vivo and in vitro approaches (e.g. immunohistochemistry, stereology, confocal and 2-
photon microscopy and 3D reconstruction, immunoblotting, PCR, cell culture). We use many
pharmacological and environmental stimuli to manipulate neurogenesis (e.g. voluntary
exercise, drug self- administration, social defeat stress) but we also have other more
sophisticated tools to do so (e.g. cranial irradiation, mitotic inhibitors, inducible
transgenic or viral gene deletion from stem cells).
If you want to know more about what my laboratory does now, visit the Eisch Laboratory
Research website. Please be sure to visit the People page to see the smiling faces of
the folks I am lucky enough to work with everyday. If you'd like to send me an email,
please click here.
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