Publications (Updated April 2011)

Publications by Ameilia J Eisch available on Pubmed


* Peer-reviewed research papers (chronological order)

* Invited articles, book chapters, and web contributions


Peer-reviewed research papers (chronological order)

  1. Eisch AJ, Gaffney M, Weihmuller FB, O'Dell SJ, Marshall JF. Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine. Brain Research. 598:321-326 (1992).
  2. Eisch AJ, O'Dell SJ, Marshall JF. Striatal and cortical NMDA receptors are altered by a neurotoxic regimen of methamphetamine. Synapse. 22:217-225 (1996).
  3. Eisch AJ, Schmued LC, Marshall JF. Characterization of cortical Fluoro-Jade labeling after a neurotoxic regimen of methamphetamine. Synapse. 30:329-333 (1997).
  4. Eisch AJ and Marshall JF. Methamphetamine neurotoxicity: Dissociation of striatal dopamine terminal damage from parietal cortical cell body injury. Synapse. 30:433-445 (1998).
  5. Eisch AJ, Lammers C-H, Yajima S, Mouradian MM, Nestler EJ. In vivo regulation of glial-derived neurotrophic factor-inducible transcription factor (GIF) by kainic acid. Neuroscience. 94:629-636 (1999).
  6. Monteggia LM, Eisch AJ, Tang MD, Kaczmarek LK, Nestler EJ. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Molecular Brain Research. 81:129-139 (2000).
  7. Messer CJ, Eisch AJ, Carlezon WA, Whisler K, Shen L, Wolf DH, Westphal H, Collins F, Russell DS, Nestler EJ. Role for GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron. 26:1-20 (2000).
  8. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ. Opiates inhibit neurogenesis in the adult rodent dentate gyrus. Proceedings of the National Academy of Sciences, USA. 97:7579-7584 (2000).
  9. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Antidepressant treatment increases the birth and survival of neurons in the adult rat hippocampus. Journal of Neuroscience. 20:9104-9110 (2000).
  10. Chen ACH, Eisch AJ, Sakai N, Takahashi M, Nestler EJ, Duman RS. Regulation of GFRalpha-1 and GFRalpha-2 mRNAs in rat brain by electroconvulsive seizure. Synapse.39:42-50 (2001).
  11. Hwang CK, D'Souza UM, Eisch AJ, Yajima S, Lammers CH, Yang Y, Lee SH, Kim YM, Nestler EJ, Mouradian MM. Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor. Proceedings of the National Academy of Sciences, USA. 98:7558-7563 (2001).
  12. Barrot MB, Olivier JDA, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V, Nestler EJ. CREB activity in the nucleus accumbens shell control gating of behavioral responses to emotional stimuli. Proceedings of the National Academy of Sciences, USA. 99:11435-11440 (2002).
  13. Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. Journal of Neuroscience, 23:3106-3111 (2003).
  14. Bolaños CA, Perrotti LI, Edwards S, Eisch AJ, Barrot M, Olson VG, Russell DS, Neve RL, Nestler EJ. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. Journal of Neuroscience, 20:7569-7576 (2003).
  15. Eisch AJ, Bolanos CA, Wit J, Simonak RD, Pudiak CM, Barrot M, Verhaagen J, Nestler EJ. BDNF in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biological Psychiatry, 54:994-1005 (2003).
  16. Mandyam CD, Norris R, Eisch, AJ. Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone. Journal of Neuroscience Research. 76:783-94 (2004).
  17. Beech RD, Cleary MA, Treloar HB, Eisch AJ, Harrist AV, Zhong W, Greer CA, Duman RS, Picciotto MR. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neuron. Journal of Comparative Neurology. 475:128-41 (2004).
  18. Harrist AV, King SL, Caldarone BJ, Zanardi A, Eisch AJ, Zoli M, Picciotto MR. Mice lacking the beta2 subunit of the neuronal nicotinic acetylcholine receptor show decreased hippocampal cell proliferation. Synapse. 54:200-6 (2004).
  19. Waugh JL, Lou AC, Eisch AJ, Monteggia LM, Muly EC, Gold SJ.Regional, cellular, and subcellular localization of RGS10 in rodent brain. Journal of Comparative Neurology. 481:299-313 (2005).
  20. Olson VG, Zabetian CP, Barrot M, Eisch AJ, Hughes T, Neve RL, Nestler EJ. Regulation of Drug Reward by CREB: Evidence for Two Functionally Distinct Subregions of the Ventral Tegmental Area. Journal of Neuroscience. 25:5553-62 (2005).
  21. D’Sa C, Eisch AJ, Bolger GB, Duman RS. Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration. European Journal of Neuroscience. 22:1463-1475 (2005).
  22. Donovan MD, Yazdani O, Norris RD, Games RD, German DC, Eisch AJ. Decreased adult hippocampal neurogenesis and granule cell number in the PDAPP mouse model of Alzheimer’s Disease. Journal of Comparative Neurology. 495:70-83 (2006).
  23. Lagace DC, Yee JK, Bolanos CA, Eisch AJ. Juvenile administration of methylphenidate attenuates adult hippocampal neurogenesis. Biological Psychiatry. 60:1121-1130 (2006).
  24. Harburg GC, Hall FS, Harrist AV, Sora I, Uhl GR, Eisch AJ. Knockout of the mu opioid receptor enhances survival of adult-generated hippocampal granule cell neurons. Neuroscience. 144:77-87 (2006).
  25. Battiste J, Helms AW, Lagace DC, Kim E, Mandyam CD, Eisch AJ, Johnson JE. Mash1 defines sequentially generated lineage restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development. 134: 285-93 (2007).
  26. Russo SJ, Bolanos CA, Theobald DE, Decarolis N, Kumar A, Renthal NE, Self DW, Russell DS, Neve RL, Eisch AJ, Nestler EJ. Insulin receptor substrate-2 in midbrain dopaminergic neurons regulates behavioral and cellular responses to opiates. Nature Neuroscience. 10: 93-9 (2007).
  27. Mandyam CD, Harburg GC and Eisch AJ. Determination of key technical aspects of precursor detection and division in the adult mouse subgranular zone. Neuroscience. 146:108-122 (2007).
  28. Lagace DC, Fischer SJ, Eisch AJ. Gender and endogenous levels of estradiol do not influence adult hippocampal neurogenesis in mice. Hippocampus. 17:175-180 (2007).
  29. Ongur D, Pohlman J, Eisch AJ, Patel TB, Edwin F, Heckers S, Cohen BM, Carlezon Jr., WA. Electroconvulsive seizures stimulate cellular proliferation and reduce expression of Sprouty within the prefrontal cortex of rats. Biological Psychiatry. 62:505-512 (2007).
  30. Mandyam CD, Wee S. Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. The Journal of Neuroscience. 27(42):11442–11450 (2007).
  31. Krishnan V, Han M-H, Graham D, Berton O, Renthal W, Laplant Q, Graham A, Russo S, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green T, Neve R, Chakravarty S, Eisch AJ, Self DW, Lee F, Tamminga C, Cooper D, Gershenfeld H, Nestler EJ. Molecular Mechanisms of Resilience in Brain Reward Regions. Cell. 131:391-404 (2007).
  32. Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, Dileone RJ, Greer CA, Mandyam CD, Eisch AJ. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. The Journal of Neuroscience. 27:12623–12629 (2007).
  33. Fischer SJ, Arguello AA, Charlton JJ, Fuller DC, Zachariou V, Eisch AJ. ­Morphine dependence and regulation of subgranular zone proliferation relies on administration paradigm.Neuroscience. 151:1217-24 (2007).
  34. Donovan MH, Yamaguchi M, Eisch AJ. Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus. Hippocampus. 18:435-439 (2008).
  35. Mandyam CD, Crawford E, Lee S, Eisch AJ, Rivier CL and Richardson HN. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Developmental Neurobiology. 68(5):575-89 (2008).
  36. Noonan MA, Choi K-H, Self DW, Eisch AJ. Withdrawal from cocaine self-administration enhances hippocampal neurogenesis, but normalizes proliferation and maturation of neural progenitors, in the adult dentate gyrus subgranular zone. The Journal of Neuroscience. 28:2516-26 (2008).
  37. Krishnan V, Graham A, Mazei-Robison MS, Lagace DC, Kim KS, Birnbaum S, Eisch AJ, Han PL, Storm DR, Zachariou V, Nestler EJ. Calcium-Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting. Biological Psychiatry. 64(4):336-43 (2008).
  38. Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biological Psychiatry. 64(11):958-65 (2008).
  39. Krishnan V, Han MH, Mazei-Robison M, Iñiguez SD, Ables JL, Vialou V, Berton O, Ghose S, Covington HE 3rd, Wiley MD, Henderson RP, Neve RL, Eisch AJ, Tamminga CA, Russo SJ, Bolaños CA, Nestler EJ. AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biological Psychiatry. 64(8):691-700 (2008).
  40. de Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC, Eisch AJ, Isascon O. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after TGFalpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells. 26(9):2349-60 (2008).
  41. Arguello AA, Harburg GC, Schonborn JR, Mandyam CD, Yamaguchi M, Eisch AJ. Time course of morphine’s effects on adult hippocampal subgranular zone reveals preferential inhibition of cells in S phase of the cell cycle and a subpopulation of immature neurons. Neuroscience,157(1):70-79 (2008).
  42. Lagace DC, Benavides DR, Kansy JW, Musacchio A, Greengard P, Bibb JA, Eisch AJ. Cdk5 is essential for adult hippocampal neurogenesis. Proceedings of the National Academy of Sciences, USA. 105(47):18567-71 (2008).
  43. Arguello AA, Fischer SJ, Schonborn JR, Markus RW, Brekken RA, Eisch AJ. Effect of chronic morphine on the dentate gyrus neurogenic microenvironment. Neuroscience. 159(3):1003-10 (2009).
  44. Gao Z, Ure K, Ables JL, Lagace DC, Nave K-A, Goebbels S, Eisch AJ, Hsieh J. Essential role of NeuroD in the survival and maturation of newborn neurons in the adult mammalian brain. Nature Neuroscience, Sep;12(9):1090-2 (2009). *** Commented on in Nature Neuroscience Sep;12(9):1079-81 (2009) Recommended article, Faculty of 1000 Biology ***
  45. Coremans V, Ahmed T, Balschun D, D’Hooge R, De Vriese A, Cremer J, Antonucci F, Moons M, Baekelandt V, Reumers V, Cremer H, Eisch AJ, Lagace DC, Janssens T, Bozzi Y, Caleo M, Conway EM. Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin. BMC Neuroscience, 11:2 (2010).
  46. Noonan MA, Bulin SA, Fuller D, Eisch AJ. Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of addiction. The Journal of Neuroscience, 30(1):304-315 (2009). *** Featured in Nature, Research Highlights, 1/14/10 doi:10.1038/463138b ***
  47. Lagace DC, Donovan MH, Farnbauch LA, DeCarolis NA, Berton O, Nestler EJ, Krishnan V, Eisch AJ. Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance. Proceedings of the National Academy of Sciences, USA. 107(9):4436-41 (2010).
  48. Li L, Harms KH, Ventura PB, Lagace DC, Eisch AJ, Cunningham LA. Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic. Glia, 58(13):1610-9 (2010).
  49. Ables JL, DeCarolis NA, Johnson MA, Rivera PD, Gao Z, Cooper DC, Radtke F, Hsieh J, Eisch AJ. Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. The Journal of Neuroscience, 30(31):10484-92 (2010). *** Recommended article, Faculty of 1000 Biology ***
  50. Zaccaria KJ, Lagace DC, Eisch AJ, McCasland JS. Autistic-like behavioral phenotype in GAP43 deficient mice. Genes, Brain, and Behavior, 2010 9(8):985-96 (2010).
  51. LaPlant Q, Vialou V, Covington III HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolanos CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience. 13(9):1137-1143 (2010). *** Commented on in Nature Neuroscience 13(9):1041-3 (2010) ***
  52. Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han M-H, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ.. IkappaB kinase regulates social defeat stress induced synaptic and behavioral plasticity. The Journal of Neuroscience. 31(1):314-21 (2011).
  53. Bludnell J, Blaiss CA, Lagace DC, Eisch AJ, Powell. Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory. Neurobiology of Learning and Memory Feb 17 [EPub ahead of print] (2011).
  54. Kim EJ, Ables JL, Dickel LK, Eisch AJ, Johnson JE. Ascl1 defines a subset of long-term self-renewable neural stem cells in adult brain. PLoS One, Mar 31;6(3):e18472 (2011).
  55. Guo W, Allan AM, Zong R, Zhang L, Johnson EB, Schaller EG, Murthy AC, Goggin SL, Eisch AJ, Oostra BA, Nelson DL, Jin P, Zhao X. Ablation of FMRP in adult neural stem cells disrupts hippocampal-dependent learning. Nature Medicine, in press.
  56. Choi KH, Edwards S, Graham D, Larson E, Whisler/Edwards K, Simmons D, Friedman A, Walsh J, Rahman Z, Monteggia LM, Eisch AJ, Neve R, Nestler EJ, Han MH, Self DW. Reinforcement-Related Regulation of AMPA Glutamate Receptor Subunits in the Ventral Tegmental Area Enhances Motivation for Cocaine. The Journal of Neuroscience. In press.

Invited articles, book chapters, and web contributions
  1. Nestler EJ, Barrot M, DiLeone R, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of Depression. Neuron. 34:13-25 (2002).
  2. Eisch AJ and Nestler EJ. To be or not to be: Adult neurogenesis and psychiatry. Clinical Neuroscience Research. 2:93-108 (2002).
  3. Eisch AJ. Adult neurogenesis: implications for neuropsychiatry. Progress in Brain Research. 138:317-344 (2002).
  4. Eisch AJ and Mandyam CD. Drug dependence and addiction, II: Adult neurogenesis and drug abuse. American Journal of Psychiatry. 161:426 (2004).
  5. Eisch AJ and Mandyam CD. Beyond BrdU: Basic and clinical implications for analysis of endogenous cell cycle proteins in Focus on Stem Cell Research E.V. Greer (Ed). Nova Scientific. 111-142 (2004).
  6. German DC and Eisch AJ. Mouse models of Alzheimer's disease: Insight into treatment. Reviews in the Neurosciences. 15:353-369 (2004).
  7. Thome J and Eisch AJ. Neurogenesis: Relevance for pathophysiology and pharmacotherapy of psychiatric disorders (language: German). Nervenarzt. 76:11-19 (2005).
  8. Eisch AJ. The involvement of brain-derived neurotrophic factor in memory and depression. Science and Technology Yearbook. MacGraw Press. (2005).
  9. Eisch AJ and Mandyam CD. Adult neurogenesis and CNS cell cycle analysis: Novel tools for exploration of the neural causes and correlates of psychiatric disorders. D. Janigro (Ed) Cell Cycle in the Central Nervous System. Humana Press. (2005).
  10. Eisch AJ. Microscopy II: Image Analysis & 3D Reconstruction, Purdue University Cytometry Laboratories, www.cyto.purdue.edu (2005).
  11. Lagace DC and Eisch AJ. Mood stabilizing drugs: Are their neuroprotective aspects clinically relevant? Psychiatric Clinics of North America. 28:399-414 (2005).
  12. Eisch AJ. Common neural adaptations and bidirectional influences of stress and addiction: Recent insights from basic research. Journal of Dual Diagnosis. 1:25-46 (2005).
  13. Eisch AJ and Harburg GC. Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology. Hippocampus. 16:271-286 (2006).
  14. Noonan MA and Eisch AJ. In vivo regulation of neural progenitors by cannabinoids. Chemistry Today. 24:28-32 (2006).
  15. Lagace DC, Noonan MA, Eisch AJ. Hippocampal neurogenesis: a matter of survival. American Journal of Psychiatry. 164:205 (2007).
  16. Eisch AJ and Mandyam CD. Adult neural progenitors: Can analysis of endogenous cell cycle proteins move us “beyond BrdU”? Current Pharmaceutical Biotechnology. 8:147-165 (2007).
  17. DeCarolis NA, Wharton KA, Eisch AJ. Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging. BioEssays. 30: 102-106 (2008).
  18. Eisch AJ, Cameron HA, Encinas JM, Meltzer LA, Ming G-L, Wadiche-Overstreet LS. Adult neurogenesis, mental health, and mental illness: Hope or hype? The Journal of Neuroscience. 28(46):11785-91 (2008).
  19. Johnson MA, Ables JL, Eisch AJ. Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches. BMB Reports. 42(5): 245-259 (2009).
  20. Jessberger S, Gage FH, Eisch AJ, Lagace DC. Making a Neuron: Cdk5 in Embryonic and Adult Neurogenesis. Trends in Neuroscience. 32(11):575-82 (2009).
  21. DeCarolis NA and Eisch AJ. Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation. Neuropharmacology. 58(6):884-93 (2010).
  22. Hsieh J and Eisch AJ. Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiology of Aging. 39(1):73-84 (2010).
  23. Ables JL, Breunig JJ, Eisch AJ*, Rakic P*. Not(ch) Just Development: Notch signaling in the Adult Brain. Nature Reviews Neuroscience. In press. *co-corresponding authors
  24. Bulin SE, Sankararaman A, Masiulis I, Rivera PD, Eisch AJ. Addiction, hippocampal neurogenesis, and neuroplasticity in the adult brain. In Encyclopedia of Addictive Behaviors. Editor PG Miller. In press.

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