Request for Funding

Medical Student Research Fellowship for Summer 2001

Mentor: Kevin W. Klein, M.D.

Department: Anesthesiology and Pain Management

Room number: CS02.708

Mail Code: 9068

Phone number: 214-648-7820

E-mail: kevin.klein@utsouthwestern.edu

Project title:

a) A prospective, randomized, double-blind, placebo-controlled trial to evaluate the analgesic efficacy and safety of oral dose of acetaminophen, rofecoxib or a combination of acetaminophen and rofecoxib for postoperative pain relief in outpatients undergoing ENT surgery.

b) A prospective, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of oral dose of celecoxib, ibuprofen or rofecoxib for postoperative pain relief in outpatients undergoing orthopedic surgery

Human subjects IRB approved projects number (where applicable): a) 1299-529; b) 0500-228

Animal subjects IRB approved project number (where applicable): n/a

Project Type: patient-based research

Brief Description of Project:

The purpose of these research protocols is to evaluate the postoperative pain relieving effect and safety of: a) acetaminophen and rofecoxib, alone or in combination, and b) celecoxib, ibuprofen or rofecoxib, taken orally 30 minutes before anesthesia induction in patients undergoing ENT (otorrhinolaryngology) and orthopedic surgery, respectively.

A total of 200 patients in each study will be assigned to one of the four treatment groups to receive:

a) 1) Acetaminophen; 2) rofecoxib; 3) acetaminophen and rofecoxib; or 4) placebo (vitamin C).

b) 1) Placebo (vitamin C); 2) celecoxib; 3) ibuprofen; or 4) rofecoxib.

Pain, nausea and vomiting will be evaluated every 30 minutes in the postanesthesia care unit and 24 hours after surgery.

Previous Research Activities or Publications with Medical Students:

1. Wong JK, Tongier WK, Armbruster SC, White PF. Use of intubating mask airway to facilitate awake orotracheal intubation in patients with cervical spine disorders. J Clin Anesth 1999; 11: 346-8.

2. Zarate E, Watcha MF, White PF, Klein KW, Sa Rego M, Stewart DG. A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000; 90: 1352-8.

3. Shao X, Li H, White PF, Klein KW, Kulstad C, Owens A. Bisulfite-containing propofol: is it a cost-effective alternative to Diprivan for induction of anesthesia? Anesth Analg 2000; 91: 871-5.

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