Request for Funding

Medical Student Research Fellowship for Summer 2001

Mentor: Paul F. White, Ph.D., M.D.

Department: Anesthesiology and Pain Management

Room number: F 2.208

Mail Code: 9068

Phone number: 214-648-6424

E-mail: paul.white@utsouthwestern.edu

Project title:

a) A prospective, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of a local anesthetic infusion pump system for postoperative pain relief in patients undergoing total knee or hip replacement surgery.

b) A prospective, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of a local anesthetic infusion pump system for postoperative pain relief in patients undergoing foot or ankle surgery

Human subjects IRB approved project number (where applicable): a)1100-549; b) 1200-575

Animal subjects IRB approved project number (where applicable): n/a

Project Type: patient-based research,

Brief Description of Project:

The purpose of this research is to evaluate the postoperative pain relieving effect and safety of a pain control infusion pump that slowly releases a local anesthetic at the incision site.

Patients will be assigned to one of four groups to receive either different concentrations of a local anesthetic at 2 ml/hr (knee/hip surgery) or the same concentration of a local anesthetic (0.25%) at different infusion rates (foot/ankle study).

Patients will be asked to evaluate their pain at 2, 4, 8, 24, 48 and 72 hours after surgery.

Previous Research Activities or Publications with Medical Students:

1. Wong JK, Tongier WK, Armbruster SC, White PF. Use of intubating mask airway to facilitate awake orotracheal intubation in patients with cervical spine disorders. J Clin Anesth 1999; 11: 346-8.

2. Zarate E, Watcha MF, White PF, Klein KW, Sa Rego M, Stewart DG. A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000; 90: 1352-8.

3. Shao X, Li H, White PF, Klein KW, Kulstad C, Owens A. Bisulfite-containing propofol: is it a cost-effective alternative to Diprivan for induction of anesthesia? Anesth Analg 2000; 91: 871-5.

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