Request for Funding

Medical Student Research Fellowship for Summer 2001

Mentor: Ralph P. Mason

Department: Radiology

Room number: E6.238CA

Mail Code: 9058

Phone number: 88926

E-mail: Ralph.Mason@UTSouthwestern.edu

Project title: An assessment of tumor oxygenation with fluorescent probes in response to interventions

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable):

APN 0464-01-14-1 and /or 0464-01-09-1

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Animal-based research

Brief Description of Project:

It is known that hypoxia (lack of oxygen) can impair tumor response to therapy, in particular irradiation. Thus, there is intense interest in developing methods to measure tumor oxygenation and assess changes induced in response to therapeutic interventions. The project will involve assessing tumor oxygenation using fluorescent oxygen probes.

Previous Research Activities or Publications with Medical Students:

Previous UT-Southwestern Medical Students Summer Research Internships:

Gloria Cha: 1992 finalist in 31st Southwestern Medical School Student Research Forum, David Shumaker (1991), David Riesz (1993) and Frank Cruz (1998)

Publications

"Glutathione in whole blood: a novel determination using double quantum coherence transfer proton NMR spectroscopy", R. P. Mason, G. H. Cha, G. H. Gorrie, E. E. Babcock & P. P. Antich, FEBS Letters, 318(1), 30-34 (1993)

"Glutathione: a novel nmr approach to measurement in vivo", G. Cha, R. P. Mason, G. H. Gorrie, A. Constantinescu & P. P. Antich, Proc. Radiat. Res. Soc., Dallas TX, 131 (1993)

"Tumor oxygen tension: a comparison of perfluorocarbon 19F nmr probes", H. P. Shukla, R. P. Mason, W. Rodbumrung, D. Shumaker & P. P. Antich, Proc. Radiat. Res. Soc., Dallas TX, 131 (1993)

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