Request for Funding

Medical Student Research Fellowship for Summer 2002

Mentor: Ralph Shohet
Department: Internal Medicine/Cardiology
Room number: NB11.116
Mail Code: 8573
Phone number: 214-648-1413
E-mail: ralph.shohet@utsouthwestern.edu
Project title: Microarray analysis of cardiac hypertrophy

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Basic and animal based

Brief Description of Project:

We have two potential projects for a summer student:

1. We study a variety of mouse models of cardiac disease including hypertrophy and heart failure. We have developed a cardiac-specific microarray for analysis of transcriptional response in these models. The student project would involve an appropriate combination of the characterization of one of these cardiac pathophysiologies and the subsequent analysis and confimation of gene regulation.

2. We have developed a new method for delivering genes to the heart using ultrasound targeted microbubble destruction (Circulation, 101:2554, 2000). The student would work with the postdoctoral fellow engaged in applying this method to angiogenesis in the heart.

Previous Research Activities or Publications with Medical Students:

1. Stewart Spitzer - worked on clot lysis assays with a mutant tissue plasminogen activator. He was included as author of "Inhibitor Resistant Tissue Plasminogen Activator: An Improved Thrombolytic Agent in Vitro. Thromb. Haemo, 71:124-128(1994).
2. Lisa Loftus and Jeff Korcz - worked on screening of myoglobin as a candidate gene in cardiac disease.
3. Korosh Resai - worked on differential display of cardiomyopathic tissues.
4. Ajai Jain - worked on creating a cardiac endothelin transgenic mouse.

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