Request for Funding

Medical Student Research Fellowship for Summer 2002

Kevin W. Klein, MD
Department: Anesthesiology & Pain Management
Room number: F2.208
Mail Code: 9068
Phone number: 214-648-6424
E-mail: kevin.klein@utsouthwestern.edu
Project title: A prospective, randomized, double-blinded, placebo-controlled trial to evaluate the analgesic efficacy and safety of oral celecoxib, rofecoxib or hydrocodone for post-discharge pain relief in outpatients undergoing ENT surgery

Human subjects IRB approved project number (where applicable): 0102-018 with stipulations

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects): Patient-based research

Brief Description of Project:

Recent studies have demonstrated that the pre-emptive use of the oral COX-2 inhibitors, rofecoxib (VioxxÒ) and celecoxib (CelebrexÒ), can reduce pain after outpatient ENT surgery. However, these patients still experience significant pain after discharge home. The most commonly used oral analgesic for treating post-discharge pain after ambulatory surgery is the opioid hydrocodone (LortabÒ). We designed a randomized, double-blind, placebo controlled study to compare the analgesic efficacy of the new COX-2 inhibitors to hydrocodone when used to treat pain after discharge. We plan to assess the patient's level of pain and need for "rescue" analgesics, as well as side effects (e.g., nausea, vomiting, dizziness, constipation) and resumption of normal activities. Finally, all patients will be asked to evaluate their quality of recovery with respect to post-dischargepain control.

Previous Research Activities or Publications with UT Southwestern Medical Students:

Song D, Singh H, White PF, Gadhiali M, Griffin, JD, Klein KW: Optimal dose of nicardipine for maintenance of hemodynamic stability after tracheal intubation and skin incision. Anesth Analg 1997; 85: 1247-51.

Song D, Heise DA, White PF: Facial electromyography correlates with the level of sedation and pain in outpatients undergoing lithotripsy. Anesthesiology 1998; 89: A928.

Fredman B, d'Etienne BA, Taylor E, Smith I, White PF: Use of low-dose propofol vs methohexital for electroconvulsive therapy. Anesth Analg 1994; 78: S120.

Zarate E, Watcha MF, White PF, Klein KW, Sá Rêgo M, Stewart DG: A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000 90: 1352-8.

Shao X, Li H, White PF, Klein KW, Kulstad C, Owens A: Bisulfite-containing propofol: is it a cost-effective alternative to DiprivanÔ for induction of anesthesia?. Anesth Analg 2000; 91: 871-5.

Coloma M, Markowitz SD, White PF, Whitten CW, Berrisford SB: Effect of dexamethasone on the prophylactic antiemetic activity of dolasetron. Anesthesiology 2001; 95: A-40.

Kadar AG, Ing CH, White PF, Wakefield CA, Kramer BA, Clark K: Anesthesia for electroconvulsive therapy in obese patients. Anesth Analg 2002; 94: 360-1.

Issioui T, Klein KW, White PF, Watcha MF, Skrivanek GD, Jones SB, Hu J, Marple BF, Ing C: Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery. Anesthesiology (in press).

Coloma M, White PF, Markowitz SD, Whitten CW, Macaluso A, Berrisford S, Thornton K: Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy. Anesthesiology (in press).

Issioui T, White PF, Jones SB, Coleman JE, Waddle JP, Markowitz SD, Coloma M, Macalusco AD, Skrivanek GD, Ing CH: The comparative efficacy of acustimulation (ReliefBandÒ) and ondansetron (ZofranÒ) in preventing nausea and vomiting after plastic surgery. Anesthesiology (submitted for publication).

Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Jones SB, Jones DB, Berrisford SB, Wakefield CA: Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology (submitted for publication).

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