Request for Funding

Medical Student Research Fellowship for Summer 2002

Mentor: Stephanie B. Jones, MD
Department: Anesthesiology & Pain Management
Room number: F2.208
Mail Code: 9068
Phone number: 214-648-6424
E-mail: stephanie.jones@utsouthwestern.edu
Project title: A prospective, randomized, controlled trial to evaluate the optimal use of the ReliefBandÒ acustimulation device with ondansetron (ZofranÒ) for the prophylaxis of postoperative nausea and vomiting

Human subjects IRB approved project number (where applicable): 0197-2500

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects): Patient-based research

Brief Description of Project:

As a result of the high costs and side effects associated with many antiemetic drugs, non-pharmacologic approaches to preventing postoperative nausea and vomiting (PONV) have become of increasing interest to practitioners. The use of transcutaneous acupoint stimulation with the ReliefBandÒ has recently been demonstrated to be as effective as ondansetron (ZofranÒ) for preventing PONV after plastic surgery (Issioui et al, Anesth Analg, 2002; 94:S-3). However, the optimal use of this device has not been studied. We propose to compare the antiemetic efficacy of the ReliefBand were applied before, after or before and after surgery using a randomized, sham-controlled, single-blind protocol design in a patient population undergoing laparoscopic surgery with a standardized anesthetic technique. In addition to determining the incidences of PONV and the need for "rescue" antiemetic medications, patient satisfaction with their quality of recovery and resumption of normal activities will also be assessed.

Previous Research Activities or Publications with UT Southwestern Medical Students:

Song D, Singh H, White PF, Gadhiali M, Griffin, JD, Klein KW: Optimal dose of nicardipine for maintenance of hemodynamic stability after tracheal intubation and skin incision. Anesth Analg 1997; 85: 1247-51.

Song D, Heise DA, White PF: Facial electromyography correlates with the level of sedation and pain in outpatients undergoing lithotripsy. Anesthesiology 1998; 89: A928.

Fredman B, d'Etienne BA, Taylor E, Smith I, White PF: Use of low-dose propofol vs methohexital for electroconvulsive therapy. Anesth Analg 1994; 78: S120.

Zarate E, Watcha MF, White PF, Klein KW, Sá Rêgo M, Stewart DG: A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000 90: 1352-8.

Shao X, Li H, White PF, Klein KW, Kulstad C, Owens A: Bisulfite-containing propofol: is it a cost-effective alternative to DiprivanÔ for induction of anesthesia?. Anesth Analg 2000; 91: 871-5.

Coloma M, Markowitz SD, White PF, Whitten CW, Berrisford SB: Effect of dexamethasone on the prophylactic antiemetic activity of dolasetron. Anesthesiology 2001; 95: A-40.

Kadar AG, Ing CH, White PF, Wakefield CA, Kramer BA, Clark K: Anesthesia for electroconvulsive therapy in obese patients. Anesth Analg 2002; 94: 360-1.

Issioui T, Klein KW, White PF, Watcha MF, Skrivanek GD, Jones SB, Hu J, Marple BF, Ing C: Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery. Anesthesiology (in press).

Coloma M, White PF, Markowitz SD, Whitten CW, Macaluso A, Berrisford S, Thornton K: Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy. Anesthesiology (in press).

Issioui T, White PF, Jones SB, Coleman JE, Waddle JP, Markowitz SD, Coloma M, Macalusco AD, Skrivanek GD, Ing CH: The comparative efficacy of acustimulation (ReliefBandÒ) and ondansetron (ZofranÒ) in preventing nausea and vomiting after plastic surgery. Anesthesiology (submitted for publication).

Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Jones SB, Jones DB, Berrisford SB, Wakefield CA: Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology (submitted for publication).

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