Request for Funding

Medical Student Research Fellowship for Summer 2002

Mentor: Jer-Tsong Hsieh
Department: Urology
Room number: J8-144
Mail Code: 9110
Phone number: 214-648-3988
E-mail: JT.Hsieh@UTSouthwsetern.edu
Project title: Signal defects leading to metastatic prostate cancer

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Brief Description of Project:

Recently, we identified that a group of unique genes involved in modulating exogenous growth stimuli-mediated signal pathway were often impaired in metastatic prostate cancer (Endocrinology, 139, 3542, 1998; JBC, 274, 31981, 1999; Biochem. Biophys. Res. Commun., 285, 129, 2001; JBC ., 278, 27793, 2001; JBC, In press, 2002; Genomics, In press, 2002). Particularly, one of genes (i.e, DIP1/2) appears to be a novel one. This project is to characterize the physiologic function of gene and study its regulation in prostatic epithelium.

Previous Research Activities or Publications with Medical Students:

1997 Eric Smith (Medical student)
1999 Nazeer Khanani (Medical student)
2000 Linya Yang (Undergraduate student)
Yang, L., Pong, R-C., Vazquez, D., Saboorian, H., Lindberg, G., Koeneman, K.S., Sagalowsky, A., and Hsieh, J.T. (2002) Evaluating the expression of coxsackie and adenovirus receptor (CAR) in human bladder cancer patients using a new antibody. J. Urol., (submitted).

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