Request for Funding

Medical Student Research Fellowship for Summer 2002

Mentor: Raymond Quigley, MD
Department: Pediatrics
Room number: G3.254
Mail Code: 9063
Phone number: 214-648-3438
E-mail: Raymond.Quigley@utsouthwestern.edu
Project title: Mechanism of Amphotericin Induced Renal Failure

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable): submitted

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)
Animal-based

Brief Description of Project:

Amphotericin is an antifungal agent that is commonly used in clinical practice. It has known major side effects that include renal damage. The literature suggests that this may be mediated through CYP450 enzymes that are known to be abundantly expressed in the kidney and are thought to induce changes in renal blood flow. This project is designed to examine the direct effects of amphotericin on renal blood flow in rats and determine which of the CYP450 enzymes/products may be contributing to the renal damage. The student will be performing the experiments under my direct supervision.

Previous Research Activities or Publications with Medical Students:
none

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