Request for Funding

Medical Student Research Fellowship for Summer 2002

Mentor: Ralph Shohet
Department: Internal Medicine/Cardiology
Room number: NB11.116
Mail Code: 8573
Phone number: 214-648-1413
E-mail: ralph.shohet@utsouthwestern.edu
Project title: Ultrasound targeted microbubble destruction for cardiac gene expression

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable): 0699-01-11-1

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Basic and animal based

Brief Description of Project:

We have developed a new method for delivering genes to the heart using ultrasound targeted microbubble destruction (Circulation, 101:2554, 2000). The student will work with the postdoctoral fellow engaged in applying this method to angiogenesis in the heart. He will participate in experiments to generate appropriate vectors for gene expression and for optimizing expression and detecting physiological effects of these transgenes in the heart.

Previous Research Activities or Publications with Medical Students:

1. Stewart Spitzer - worked on clot lysis assays with a mutant tissue plasminogen activator. He was included as author of "Inhibitor Resistant Tissue Plasminogen Activator: An Improved Thrombolytic Agent in Vitro. Thromb. Haemo, 71:124-128(1994).
2. Lisa Loftus and Jeff Korcz - worked on screening of myoglobin as a candidate gene in cardiac disease.
3. Korosh Resai - worked on differential display of cardiomyopathic tissues.
4. Ajai Jain - worked on creating a cardiac endothelin transgenic mouse.

Return to UT Southwestern Homepage

Return to Student Research Projects Index