Medical Student Research Fellowship for Summer 2003
Mentor: Paul F. White, PhD, MD
Department: Anesthesiology & Pain Management
Room number: F2.208
Mail Code: 9068
Phone number: 214-648-6424
E-mail: paul.white@utsouthwestern.edu
Project title: A novel formulation of propofol for total intravenous anesthesia:
Effect on auditory and somatosensory evoked-potentials
Human subjects IRB approved project number (where applicable): Pending
Animal subjects IRB approved project number (where applicable): N/A
Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)
Patient-based research
Three Projects
1. Brief Description of Project:
We will be evaluating a new formulation of a popular anesthetic drug known as propofol. The new anesthetic formulation contains 50% less lipid and is preservative-free. The study will be a randomized, double-blind comparison of the new formulation (AmpofolÔ) to the "gold standard" (DiprivanÔ). In addition to evaluating the intraoperative effects of the propofol formulations using cerebral monitoring of auditory and somatosensory evoked-potentials, we plan to compare their effects on recovery times, postoperative lipid levels and side effects.
2. Brief Description of Project:
The purpose of this study is to compare the antiemetic efficacy of oral granisetron (KytrilÒ) and Ondansetron (ZofranÒ) 4 mg IV when administered for routine prophylaxis of postoperative nausea and vomiting (PONV) in patients undergoing major laparoscopic or lower abdominal surgery procedures and to perform a cost-effective analysis of the relative costs of granisetron and ondansetron to achieve a completely satisfied patient with their PONV management.
3. Brief Description of Project:
Human subjects IRB approved project number (where applicable): 020-2074
Animal subjects IRB approved project number (where applicable): N/A
Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Patient-based research
Electroconvulsive therapy (ECT) is highly effective for treating severe depression.
However, use of ECT is limited by its cognitive side effects. The side effects
and efficacy of ECT depend upon the strength and distribution of the current
induced in the brain but this is difficult to control with ECT. Stimulating
the brain indirectly with magnetic fields can be far more focal than ECT. Magnetic
Seizure Therapy (MST) also offers better control over the site of seizure onset.
Focused seizure induction could potentially target prefrontal circuitry involved
in mood, and limit spread to medial temporal lobe and other regions thought
to be critical to the memory side effects of ECT. We plan to evaluate the effect
of MST on the patient's electroencephalogram (EEG) during general anesthesia.
Previous Research Activities or Publications with Medical Students:
Song D, Singh H, White PF, Gadhiali M, Griffin, JD, Klein KW: Optimal dose of nicardipine for maintenance of hemodynamic stability after tracheal intubation and skin incision. Anesth Analg 1997; 85: 1247-51.
Song D, Heise DA, White PF: Facial electromyography correlates with the level of sedation and pain in outpatients undergoing lithotripsy. Anesthesiology 1998; 89: A928.
Fredman B, d'Etienne BA, Taylor E, Smith I, White PF: Use of low-dose propofol vs methohexital for electroconvulsive therapy. Anesth Analg 1994; 78: S120.
Zarate E, Watcha MF, White PF, Klein KW, Sá Rêgo M, Stewart DG: A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000 90: 1352-8.
Shao X, Li H, White PF, Klein KW, Kulstad C, Owens A: Bisulfite-containing propofol: is it a cost-effective alternative to DiprivanÔ for induction of anesthesia? Anesth Analg 2000; 91: 871-5.
Coloma M, Markowitz SD, White PF, Whitten CW, Berrisford SB: Effect of dexamethasone on the prophylactic antiemetic activity of dolasetron. Anesthesiology 2001; 95: A-40.
Kadar AG, Ing CH, White PF, Wakefield CA, Kramer BA, Clark K: Anesthesia for electroconvulsive therapy in obese patients. Anesth Analg 2002; 94: 360-1.
Issioui T, Klein KW, White PF, Watcha MF, Coloma M, Skrivanek GD, Jones SB, Thornton KC, Marple BF: The efficacy of premedication with celecoxib and acetaminophen in preventing pain after otolaryngologic surgery. Anesth Analg 2002; 94: 1188-93.
Issioui T, Klein KW, White PF, Watcha MF, Skrivanek GD, Jones SB, Hu J, Marple BF, Ing C: Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery. Anesthesiology 2002; 97: 931-7.
Coloma M, White PF, Markowitz SD, Whitten CW, Macaluso A, Berrisford S, Thornton K: Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy. Anesthesiology 2002; 96: 1346-50.
White PF, Issioui T, Hu J, Jones SB, Coleman JE, Waddle JP, Markowitz SD, Coloma M, Macalusco AD, Ing CH: Comparative efficacy of acustimulation (ReliefBandÒ) versus ondansetron (ZofranÒ) in combination with droperidol for preventing nausea and vomiting. Anesthesiology 2002: 97:1075-81.
Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Jones SB, Jones DB, Berrisford SB, Wakefield CA: Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology 2002: 97:1387-92.
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