Medical Student Research Fellowship for Summer 2003

Mentor: Kevin W. Klein, MD
Department: Anesthesiology & Pain Management
Room number: F2.208, CS2.620
Mail Code: 9068
Phone number: 214-648-7820
E-mail: Kevin.klein@utsouthwestern.edu
Project title: Efficacy and Safety of New COX-2 Inhibitors in Reducing Postoperative Pain for Patients Undergoing Plastic Surgery

Human subjects IRB approved project number (where applicable): Pending

Animal subjects IRB approved project number (where applicable): N/A

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Patient-based research

Brief Description of Project:

We will be evaluating the use of new COX-2 inhibiting anti-inflammatory drugs for postoperative pain relief in patients undergoing plastic surgery procedures. Patients will be assessed for pain relief in phase 1 and 2 recovery as well as post discharge. Additionally, we will assess postoperative bleeding and bruising. Although COX-2 inhibitors are thought not to significantly affect platelet function, some surgeons are reluctant to incorporate these drugs into their clinical practice without evidence of safety in this patient population.

Previous Research Activities or Publications with Medical Students:

Song D, Singh H, White PF, Gadhiali M, Griffin, JD, Klein KW: Optimal dose of nicardipine for maintenance of hemodynamic stability after tracheal intubation and skin incision. Anesth Analg 1997; 85: 1247-51.

Song D, Heise DA, White PF: Facial electromyography correlates with the level of sedation and pain in outpatients undergoing lithotripsy. Anesthesiology 1998; 89: A928.

Fredman B, d'Etienne BA, Taylor E, Smith I, White PF: Use of low-dose propofol vs methohexital for electroconvulsive therapy. Anesth Analg 1994; 78: S120.

Zarate E, Watcha MF, White PF, Klein KW, Sá Rêgo M, Stewart DG: A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000 90: 1352-8.

Shao X, Li H, White PF, Klein KW, Kulstad C, Owens A: Bisulfite-containing propofol: is it a cost-effective alternative to DiprivanÔ for induction of anesthesia? Anesth Analg 2000; 91: 871-5.

Coloma M, Markowitz SD, White PF, Whitten CW, Berrisford SB: Effect of dexamethasone on the prophylactic antiemetic activity of dolasetron. Anesthesiology 2001; 95: A-40.

Kadar AG, Ing CH, White PF, Wakefield CA, Kramer BA, Clark K: Anesthesia for electroconvulsive therapy in obese patients. Anesth Analg 2002; 94: 360-1.

Issioui T, Klein KW, White PF, Watcha MF, Coloma M, Skrivanek GD, Jones SB, Thornton KC, Marple BF: The efficacy of premedication with celecoxib and acetaminophen in preventing pain after otolaryngologic surgery. Anesth Analg 2002; 94: 1188-93.

Issioui T, Klein KW, White PF, Watcha MF, Skrivanek GD, Jones SB, Hu J, Marple BF, Ing C: Cost-efficacy of rofecoxib versus acetaminophen for preventing pain after ambulatory surgery. Anesthesiology 2002; 97: 931-7.

Coloma M, White PF, Markowitz SD, Whitten CW, Macaluso A, Berrisford S, Thornton K: Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy. Anesthesiology 2002; 96: 1346-50.

White PF, Issioui T, Hu J, Jones SB, Coleman JE, Waddle JP, Markowitz SD, Coloma M, Macalusco AD, Ing CH: Comparative efficacy of acustimulation (ReliefBandÒ) versus ondansetron (ZofranÒ) in combination with droperidol for preventing nausea and vomiting. Anesthesiology 2002: 97:1075-81.

Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Jones SB, Jones DB, Berrisford SB, Wakefield CA: Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology 2002: 97:1387-92.

Return to UT Southwestern Homepage

Return to Student Research Projects Index