Medical Student Research Fellowship for Summer 2003

Mentor: David Mangelsdorf

Department: Pharmacology

Room number: L3.110

Mail Code: 9050

Phone number: x86349

E-mail: davo.mango@utsouthwestern.edu

Project title: The Role of LXRs in Skin

Human subjects IRB approved project number (where applicable): N/A

Animal subjects IRB approved project number (where applicable): 0693-02-02-1

Project Type (patient-based research, animal-based research, or basic
research; this characterization is only to permit a general classification
for grouping similar types of projects): animal based research

Brief Description of Project:

The hypothesis is that lipid metabolism in skin is mediated by LXRs.
The specific aims for this project are:
1. to evaluate the expression of LXRa and b in skin, sebaceous glands, and preputial glands.
2. to determine if LXR agonists can induce specific changes in lipid metabolism and hair growth in skin.
We will utilize LXR-null mice to study follicle and sebocyte proliferation, sebaceous lipid secretion and composition, and hair production with and without LXR agonist treatment.

Previous Research Activities or Publications with Medical Students: None (excluding MSTP students)

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