Request for Funding

Medical Student Research Fellowship for Summer 2004

Mentor: Peter Igarashi, M.D.

Department: Internal Medicine/Nephrology

Room number: H5.122

Mail Code: MC8856

Phone number: 214-648-2754

E-mail: peter.igarashi@utsouthwestern.edu

Project title: Mouse models of polycystic kidney disease

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable): 0862-00-03-1

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Animal-based research

Brief Description of Project:

Polycystic kidney disease (PKD) is the most common genetic cause of kidney failure in humans. Two forms are recognized: autosomal dominant PKD affects primarily middle-aged adults, and autosomal recessive PKD affects infants and children. The goal of our research is to understand the molecular pathogenesis of PKD using animal models. Our laboratory produces transgenic and knockout mice that develop kidney cysts. The mutant mice are studied using cell biological and biochemical methods to identify the mechanism responsible for cyst formation.

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