Request for Funding

Medical Student Research Fellowship for Summer 2004

Mentor: W. Matthew Petroll
Department: Ophthalmology
Room number: E7.234
Mail Code: 9057
Phone number: 8-7216
E-mail: matthew.petroll@utsouthwestern.edu
Project title: Assessment of extracellular matrix reorganization by corneal fibroblasts

Human subjects IRB approved project number (where applicable): NA

Animal subjects IRB approved project number (where applicable): NA

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Basic Research

Brief Description of Project:

Reorganization or extracellular matrices by cells is important during wound healing and embryonic development. We have developed an experimental model for studying the reorganization of collagen matrices by corneal fibroblasts using time-lapse 3-D imaging. In this project, we will use our model to investigate how specific growth factors modulate cell-induced matrix reorganization.

Previous Research Activities or Publications with Medical Students:

Kovoor TA, Kim AS, McCulley JP, Cavanagh HD, Jester JV, Budge AC, Petroll WM. Evaluation of the corneal effects of topical ophthalmic fluoroquinolones using in vivo confocal microscopy. Eye Contact Lens (In Press).

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