Request for Funding

Medical Student Research Fellowship for Summer 2004

Mentor: Ralph Shohet
Department: Internal Medicine/Cardiology
Room number: NB10.230
Mail Code: 8573
Phone number: 214-648-1413
E-mail: ralph.shohet@utsouthwestern.edu
Project title: Microarray analysis of cardiovascular disease

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Basic and animal based

Brief Description of Project:

We study a variety of mouse models of cardiovascular disease including exogenous stimuli (smoking, air pollution, hypertrophy) and transgenic manipulation. We use microarrays and real-time PCR for analysis of transcriptional response in these models. The student project would involve an appropriate combination of the characterization of one of these cardiac pathophysiologies and the subsequent analysis and confirmation of gene regulation. One possibility would be to examine the effects of streptozocin induced diabetes on endothelial gene regulation.

Previous Research Activities or Publications with Medical Students:

1. Stewart Spitzer - worked on clot lysis assays with a mutant tissue plasminogen activator. He was included as author of "Inhibitor Resistant Tissue Plasminogen Activator: An Improved Thrombolytic Agent in Vitro. Thromb. Haemo, 71:124-128(1994).
2. Lisa Loftus and Jeff Korcz - screened of myoglobin as a candidate gene in cardiac disease.
3. Korosh Resai - worked on differential display of cardiomyopathic tissues.
4. Ajai Jain - worked on creating a cardiac endothelin transgenic mouse.
5.Shaib Abdullah - worked on MAPK phosphorylation by endothelin
6. Jason Willis - worked on the microbubble project
7. Jason Schaefer 2003 - worked on transcriptional control of a gene regulated in heart failure

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