Request for Funding

Mentor: Dr. Michael D. Devous, Sr.
Department: Radiology / Nuclear Medicine Center
Room number: E6.120
Mail Code: 9061
Phone number: 214 648-3315
E-mail: Michael.Devouos@UTSouthwestern.edu
Project title: Network systems in speech and language

Human subjects IRB approved project number (where applicable): N/A (student will be working with data already collected)

Animal subjects IRB approved project number (where applicable): N/A

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) patient based

Brief Description of Project:
Functional Brain Imaging has been used to study speech and language processing in normal controls and in cochlear implant subjects under a variety of conditions. These data provide insight into the disturbances in the neuroanatomical substrate of speech and language as modified by deafness and its restoration following cochlear implantation. This project will focus on identifying neural networks associated with successful speech perception in normal subjects and with a range of speech perception performance in cochlear implant patients.

Previous Research Activities or Publications with Medical Students:
I have an ongoing research program that involves a number of students and faculty. This has derived in part from students contacted in the following teaching environments:
1) Functional Brain Imaging, subsection of MS-4 Radiology, 1984- present
2) Functional Brain Imaging in Psychiatry, PGY-2 and 3 Psychiatry lectures, 1998-present
3) Course Director and faculty member: Advanced fMRI Training Course, January 2002.
4) Fundamentals of Functional Brain Imaging, graduate lecture course for the Radiological Sciences Program
5) Advanced Principles of Functional Brain Imaging, graduate lecture course
6) Laboratory Rotation, Functional Brain Imaging, Biomedical Engineering Program
7) Course Director and faculty member: The Brain Imaging Practica.
Further, I have had the following medical students and fellows working in my lab:
Robert W. Kowatch, M.D., Ph.D., Trained (1995-2000) as a consequence of a K07 training grant (K07-MH01057-01) (MD Devous, mentor) focusing on functional brain imaging studies of pediatric patients with mood disorders.
Madhukar H. Trivedi, M.D. Trained (1991-1994) in functional brain imaging (MD Devous, mentor) as a consequence of both a NARSAD fellowship and NIH/NIMH Minority Supplement to the MHCRC
John R. Debus, M.D. Trained (1988-1990) in functional brain imaging (MD Devous, mentor) as a consequence of a NARSAD fellowship.

Recent publications including graduate and medical students include:
Haley RW, Hom J, Roland PS, Bryan WW, Van Ness PC, Bonte FJ, Devous MD Sr, Mathews D, Fleckenstein JL, Wians FH Jr, Wolfe GI, Kurt TL. Evaluation of Neurologic Function in Gulf War Veterans: A Blinded Case-Control Study. JAMA 277:223-230, 1997

Kowatch RA, Devous MD Sr, Harvey DC, Mayes TL, Trivedi MH, Emslie GJ, Weinberg WA: A SPECT HMPAO study of regional cerebral blood flow in depressed adolescents and normal controls. Prog Neuro-Psychopharmacol & Biol Psychiat 23: 643-656, 1999

Adinoff B, Devous MD, Best S, George MS, Alexander D, Payne K. SPECT following intravenous Procaine in Cocaine Addiction. Advancing from the Ventral Striatum to the Extended Amygdala: Implications for Neuropsychiatry and Drug Abuse. Annals New York Acad Sci 877:807-810, 1999

Haley RW, Fleckenstein, JL, Bonte FJ, Devous MD, Marshall WW, McDonald, GG, Petty, F. Brain Abnormalities in Gulf War Syndrome: Evaluation with 1H MR Spectroscopy. Radiology 2000;215:807-817

Devous MD Sr, Trivedi MH, Rush AJ: Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteers. J Nucl Med 42:535-542, 2001

Bonte FJ, Trivedi MH, Devous MD Sr, Harris TS, Payne JK, Weinberg WA, Haley RW. Occipital Brain Perfusion Deficits in Children with Major Depressive Disorder. J Nucl Med 42:1059-1061, 2001

Adinoff B, Devous MD Sr, Best SE, Chandler P, Harris T, Payne JK, Frock S, Williams MJ. Regional cerebral blood flow in female cocaine-addicted subjects following limbic activation. Drug and Alcohol Dependence 71 255-268, 2003

Trivedi MH, Devous MD Sr, Grannemann BD, Rush AJ, Cain JW, Debus JR: Regional cerebral blood flow in obsessive-compulsive disorder: A SPECT study of 26 drug-free patients and 138 normal controls. Psych Res: Neuroimaging. In Press

Roland P, Tobey E, Devous M, Harris T, Waller M, Barco A, D'Haese P. Central Processing in Cochlear Implant Users as Measured by SPECT. Excerpta Medica International Congress Series: XVII World Congress of the International Federation of Oto-Rhino-Laryngological Society. R. Ruben (Ed). In Press

Devous MD Sr, Altuna D, Furl N, Cooper W, Gabbert G, Ngai WT, Chiu S, Scott JM III, Harris TS, Payne JK, Tobey EA. Functional neuroanatomy of brain areas dominant for speech and language in pediatric normal controls. Journal of Speech, Language, and Hearing Research. In Press

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