Request for Funding

Mentor: Ugis Gruntmanis
Department: Medicine/Endocrinology
Room number: J6,110
Mail Code: 8857
Phone number: 214-648-2215
E-mail: ugis.gruntmanis@utsouthwestern.edu
Project title: 1. Efficacy of testosterone, biphosphonates and combination of both in treatment of male osteoporosis.
2. A Randomized, double-masked, placebo-controlled pilot trial of testosterone gel in patients with kidney disease requiring dialysis and hypogonadism for the treatment of metabolic bone disease.
Human subjects IRB approved project number (where applicable):
0102-022

Animal subjects IRB approved project number (where applicable):
N/A

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects). Both of the projects are patient oriented.

Brief Description of Project:

1. First project is a retrospective study comparing efficacy of three different treatments for male osteoporosis. As many as half a million males have osteoporosis related fractures annually, yet not data is available on comparative efficacy between two most commonly used treatment regimens in male osteoporosis. Our study will strive to answer this important question.

2. Similarly, male patients with end-stage renal disease suffer from 4x increased risk of bone fractures, decreased life quality and sexual dysfunction. Many of them have also low testosterone levels (male sex hormone). We postulate that replacing testosterone to normal level, it will decrease the risk of bone fractures, will improve life quality and sexual function.

Previous Research Activities or Publications with Medical Students:

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