Request for Funding

Mentor: Darren K. McGuire
Department: Internal Medicine/Cardiology
Room number: HA9.133
Mail Code: MC 9047
Phone number: 214 645 7500
E-mail: darren.mcguire@utsouthwestern.edu
Project title: PACE-Rx Study

Human subjects IRB approved project number (where applicable): #0103-026

Animal subjects IRB approved project number (where applicable):

Project Type -patient-based research

Brief Description of Project:
Prospective randomized study evaluating the effect of a physician extender applying a disease-management algorithm added to usual care/follow-up versus usual care alone. Patients are screened in Parkland Hospital at the time of hospital discharge after an acute coronary syndrome/acute MI event, and those eligible are invited to participate and informed consent obtained. In a 1:1 randomization, volunteer participants are randomized to follow up with a Nurse Practictioner within 2 weeks in addition to usual appointments with cardiology and primary care providers versus just the cardiology/primary care.
Primary parameters of interest are at 6-months and 1-year, proportion of patients prescribed aspirin, ACE inhibitors, statins, and beta-blockers; proportion of patients at or below clinical care guideline targets for blood pressure and LDL cholesterol.

Previous Research Activities or Publications with Medical Students:

Evaluation of Diabetes-related Knowledge with Duke Medical Student, Carlos Sanchez.
Sanchez CD, McGuire DK, Feinglos MN, Hasselblad V, Newby LK, Ohman EM. Diabetes-Related Knowledge Is Not Associated With Measures of Risk Factor Control in Patients With Diabetes and Acute Coronary Syndromes. J Am Coll Cardiol 2002;39:443A.(abstract)

Sánchez CD, Newby LK, McGuire DK, Hasselblad V, Feinglos MN, Ohman EM. Diabetes-related knowledge is not associated with measures of risk factor control or cardiac outcomes in patients with diabetes and acute coronary syndromes. In review

Case report with UTSW medical student, Jay Kutnick.
Aslam MK, Gnaim C, Kutnick J, Kowal RC, McGuire DK. Syndrome of inappropriate anti-diuretic hormone secretion induced by amiodarone therapy. PACE 2004; In Press

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