Request for Funding

Mentor: Babatunde Ogunnaike, MD
Department: Anesthesiology and Pain Management
Room number:
Mail Code: 9068
Phone number: 214 590 8536
E-mail: babatunde.ogunnaike@utsouthwestern.edu
Project title: Dexmedetomidine for sedation in ICU: Comparison with current techinques

Human subjects IRB approved project number (where applicable): 1003-628

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)
Patient-based research

Brief Description of Project:

The study will be conducted in 50 critically ill patients expected to require a minimum of 6 hours (up to 24 hours) of sedation. Each patient will receive either dexmedetomidine or any of the currently approved drugs (midazolam, morphine or lorazepam) used for sedation in critically ill patients. Patients will be frontloaded either with 1mcg/kg dexmedetomidine slowly over 10-20 minutes, followed by a continuous infusion of 0.2-0.7 mcg/kg/hr or midazolam by continuous infusion of 0.05-0.2 mg/kg/hr IV or morphine 0.8-10 mg/hr IV or lorazepam 2-5 mg/hr IV. The bispectral index (BIS) monitor will be used to titrate sedation to maintain a value of 70±5. BIS will also be used, in addition to regular ICU sedation scores, to adjust drug dosages in study subjects. Patients will be randomized into either of the 2 groups using computer-generated numbers. Randomization will be done after the patient is admitted to the ICU and as soon as informed consent is obtained. Data collected will include patient demographics (e.g. age, height, weight, gender), diagnosis, reason for ICU admission and date and time of ICU admission. The ability to maintain a predetermined bispectral index, the occurrence of hemodynamic adverse events as well as sedation scores will be recorded.

Previous Research Activities or Publications with Medical Students: (Medical students' named written in bold letters and underlined)

1. Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Jones SB, Jones DB, Berrisford SB, Wakefield BS. Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology 2002; 97: 1387-92
2. Recart A, Gasanova I, White PF, Thomas T, Ogunnaike B, Hamza M, Wang A. The effect of cerebral monitoring on recovery after general anesthesia: a comparison of the auditory evoked potential and bispectral index devices with standard clinical practice. Anesth Analg 2003; 97: 1667-74

3. Coloma M, Ogunnaike BO, White PF, Lee AQ, Brown PM, Wakefield CA. Comparative analgesic efficacy of ibuprofen, ketorolac and rofecoxib in preventing pain after ambulatory surgery. 2002 Annual SAMBA Meeting Supplement

4. Hamza MA, White PF, Ogunnaike B, Gasanova I, Lo M, Joshi G. Oral granisetron vs ondansetron for antiemetic prophylaxis in outpatients undergoing laparoscopic surgery: a randomized, double-blind comparison. Anest Analg 2004; 98: S-12

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