Request for Funding

Mentor: Helen H. Hobbs, M.D.
Department: McDermott Center
Room number: NB10.204A
Mail Code: 8591
Phone number: 214-648-6724
E-mail: helen.hobbs@utsouthwestern.edu
Project title:

Human subjects IRB approved project number (where applicable): 1287-35500

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Brief Description of Project: Plasma levels of cholesterol are directly related to the dietary content of cholesterol and to the fractional absorption of dietary cholesterol. The fractional absorption of cholesterol varies over a wide range and is directly related to the plasma levels of campesterol, as major plant sterol. We measured the plasma levels of campesterol in the Dallas Heart Study and will be examining the genetic factors that contribute to the inter-individual differences in plasma campesterol levels by performing genetic association studies and linkage studies with a goal of pinpointing the genetic variations contributing to differences in cholesterol absorption.

Previous Research Activities or Publications with Medical Students:

Yu, L., York, J., von Bergmann, K., Lutjohann, D., Cohen, J.C., Hobbs, H.H. (2003) Stimulation of cholesterol excretion by LXR agonist requires ATP-binding cassette transporters G5 and G8. J. Biol. Chem., 278:15565-70.

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