Request for Funding

Medical Student Research Fellowship for Summer 2004

Mentor: David J. Mangelsdorf, Ph.D.
Department: Pharmacology/HHMI
Room number: L3.110
Mail Code: 9050
Phone number: 214-648-6349 or Betsy @ 85417
E-mail: davo.mango@utsouthwestern.edu
Project title:

Human subjects IRB approved project number (where applicable): N/A

Animal subjects IRB approved project number (where applicable): 0693-03-02; 0693-02-3

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Brief Description of Project:

A variety of on-going projects in the laboratory will be looking at the roles of various nuclear receptors that regulate lipid metabolism, with particular emphasis on: 1) skin and alopecia, 2) colon cancer. These studies involve animal-based and basic research funded by HHMI and the NIH (pending grant #).


Previous Research Activities or Publications with Medical Students:

1. Bryan Ong - student who studied LXR and oxysterol signaling in skin and its potential role in androgenetic alopecia (Summer, 2003).


2. Reese Graves - student who set up the DNA sequencing strategy to look for polymorphisms and/or mutations in the vitamin D receptor from patients with colorectal cancer (Summer, 2003).



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