Medical Student Research Fellowship for Summer 2005

Mentor: Hsieh, Jer-Tsong
Department: Urology
Room number: J8-146
Mail Code: 9110
Phone number: 8-3988
E-mail: jt.hsieh@utsouthwestern.edu
Project title: DEVELOPING A NEW PROSTATE CANCER THERAPEUTIC REGIMEN ASSISTED WITH NON-INVASIVE MOLECULAR IMAGING AND PROTEOMIC TECHNIQUES

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Brief Description of Project:

In this project, we are planning to develop a new regimen to target metastatic prostate cancer by combining several novel agents that can modify epigenetic gene regulation. We will employ two animal models to examine the efficacy of this regimen. To evaluate therapeutic efficacy, we will employ non-invasive molecular imaging tools to determine the response of tumor cell. In addition, we will profile serum protein pattern using mass spectrometry.

Previous Research Activities or Publications with Medical Students:
Karam J., Mason, R., Koeneman, K., Antich, P.P., Benaim, E., and Hsieh, J.T. (2003) Molecular imaging in prostate cancer. J. Cell. Biochem., 90, 473-483.
Karam J., Benaim, E., Chen, H., Pong, R.C., and Hsieh, J.T. (2005) Epigenetics in prostate cancer. In Prostate Cancer: Mechanisms, Prevention, and Hormone Therapy (Chang, C., ed) (submitted)

Svatek R., Herman, M.P., Lotan Y., Casella R., Hsieh J.T., Sagalowsky, A.I., and Shariat S.F. (2005) Urinary levels of soluble fas are elevated in patients with transitional cell carcinoma of the urinary bladder. (In preparation)

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