Medical Student Research Fellowship for Summer 2006

Mentor: Darren McGuire, MD, MHSc
Department: Internal Medicine/Cardiology
Room number: HA9.133
Mail Code: 9047
Phone number: 214 645 7520
E-mail: darren.mcguire@utsouthwestern.edu
Project title: 1. Cardiovascular effects of rosiglitazone versus placebo
2. TRIUMPH acute coronary syndrome registry

Human subjects IRB approved project number (where applicable): 1. 082004-017; 2. 032005-044

Animal subjects IRB approved project number (where applicable): N/A

Project Type Patient-based research (1. Randomized clinical trial; 2. Observational registry)

Brief Description of Project:
1. Randomized study of rosiglitazone versus placebo in patients with type 2 diabetes with or at risk for cardiovascular disease. Assessing exercise testing parameters, cardiac MRI, and cardiac spectroscopy (detects intra-myocyte triglyceride content).
2. TRIUMPH study is enrolling consecutive patients admitted to Parkland hospital with diagnosis of acute coronary syndrome. Collection of extensive health history information using survey/interview and data abstraction from medical records with computer data entry.

Previous Research Activities or Publications with Medical Students:
-2 students spent 2 summers completing a randomized study of post-MI care strategies; just completed database and in process of writing manuscript (students are co-primary authors)
-2 students launched the TRIUMPH registry recruitment last summer; no scientific output yet from this early multi-center project

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