Medical Student Research Fellowship for Summer 2006

Mentor: V. Vinod Mootha, MD
Department: Ophthalmology
Room number: E5-704
Mail Code: 9057
Phone number: 214-648-4733
E-mail: vinod.mootha@utsouthwestern.edu
Project title: Abnormal Gene Expression in Keratoconus

Human subjects IRB approved project number (where applicable): 022205-073

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Patient-based

Brief Description of Project: Microarray analysis of keratocytes isolated from keratoconus keratoplasty specimens have implicated several genes of interest. This project involves immunohistochemical confirmation of abnormal gene products using archived keratoplasty specimens. This project would be supervised by an experienced immunohistochemistry technician.

Previous Research Activities or Publications with Medical Students:

Ogirala GK, Davids HR, Raju VK, & Mootha VV*. Nematode in Anterior Chamber. Archives of Ophthalmology. 2003; 121:1338-1339. (University of New Mexico Health Sciences Center)

Shahinpoor P, Wood M, Overturf G, Mootha VV*. Conjunctival Ulceration associated with Primary Herpes Simplex Virus Blepharoconjunctivitis. Morning Rounds: "A Small Angel with a most Peculiar Finding." EyeNet. June 2004; 39-40 (University of New Mexico Health Sciences Center)

Mootha VV*, Pingree M, Jaramillo J. Pterygia with Deep Corneal Changes. Cornea. 2004; 23(6): 635-38 (University of New Mexico Health Sciences Center)

Zev Shulkin, Research and Clinical Mentor, "Descemet's Membrane Thickness in Fuchs' Dystrophy, August 2005 (UTSW)

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