Medical Student Research Fellowship for Summer 2006

Mentor: Dr. Robert Greene
Department: Psychiatry
Room number: NC5.112H
Mail Code: 5323 Harry Hines Blvd
Dallas TX 75390-9070
Phone number: 214-648-5108
E-mail: Robertw.greene@UTSouthWestern.edu
Project title: Localized NMDA receptor-dependent function in cognition

Human subjects IRB approved project number (where applicable): na

Animal subjects IRB approved project number (where applicable): 0924-05-04-1

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)
animal-based

Brief Description of Project:
We will employ a localized, targeted, gene deletion technique, developed in our lab, to examine the role of NMDARs in the dentate subfield of the hippocampus in hippocampal-dependent learning and memory. The learning and memory task, that we plan to employ, was also developed and validated in our lab to have particular relevance for learning and memory deficits associated with thought disorder of psychosis.

Previous Research Activities or Publications with Medical Students:
These are only papers that were published with Medical students (names are in bold) and does not include papers with residents.

1. Bergeron R, Meyer TM, Coyle JT, Greene RW (1998) Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A 95: 15730-15734.
2. Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene RW, Nestler EJ (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101: 10827-10832.

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