Medical Student Research Fellowship for Summer 2007

Mentor: Emmanouil S. Brilakis, MD, PhD
Department: Cardiology
Room number: VA 5A
Mail Code: 111A
Phone number: 214-857-1547
E-mail: esbrilakis@yahoo.com
Project title: The SOS (Stenting Of Saphenous vein grafts) randomized-controlled trial

Human subjects IRB approved project number (where applicable): 80

Animal subjects IRB approved project number (where applicable): NA

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Patient-base research

Brief Description of Project:

The SOS is a prospective, multicenter, randomized-controlled study that will randomize 80 consecutive patients undergoing stenting of a de novo or restenotic saphenous vein graft lesion in a 1:1 ratio to the uncoated Express2 stent or the identical design Taxus paclitaxel-eluting stent in order to determine:

(1) whether the Taxus paclitaxel-eluting stent will reduce the incidence of binary angiographic in-stent restenosis as assessed by 12-month follow-up quantitative coronary angiography (primary study endpoint), and

(2) whether the Taxus paclitaxel-eluting stent will achieve the following secondary study endpoints:
(a) reduce intra-stent intimal hyperplasia volume accumulation at 12-months, as measured by intravascular ultrasound
(b) reduce the 24-month incidence of:
" ischemia-driven target vessel revascularization
" target vessel failure, and
" overall major adverse cardiac and cerebrovascular events

Approximately 2/3 of enrollment has been completed.

Previous Research Activities or Publications with Medical Students:

Iturbe JM, Banerjee S, Brilakis ES. Exertional dyspnea due to spontaneous coronary artery dissection in a 55-year-man. Heart 2007, in press

Return to Medical Student Research Page