Medical Student Research Fellowship for Summer 2007

Mentor: Shawna Nesbitt MD.
Department: Internal Medicine/ Hypertension Division
Room number: CS8.102
Mail Code: 8899
Phone number: 214-648-2103
E-mail: shawna.nesbitt@utsouthwestern.edu

3 Projects listed below

I. Project title: Evaluation of VALsartan's Uniqueness And Twenty-Four hour Blood Pressure Efficacy: EVALUATE
Human subjects IRB approved project number (where applicable): IRB: 012007-038

Animal subjects IRB approved project number (where applicable):

Project Type: Patient Based Research

Brief Description of Project This is a double-blind study to evaluate the reduction in systolic blood pressure (24-hour ABPM) using therapy initiated with valsartan 160 mg and titrated to a maximum dose of valsartan/HCTZ (320/25 mg), compared to treatment initiated with amlodipine 5 mg and titrated to a maximum dose of amlodipine/HCTZ (10/25 mg).

II. Project title: Hemodynamics in Progression to Hypertension

Human subjects IRB approved project number (where applicable):
Animal subjects IRB approved project number (where applicable):

Project Type: Patient Based Research

Brief Description of Project: Annual plethysmography traces from the 4-year TROPHY study will be analyzed to determine if progression to hypertension is associated with hemodynamic changes and whether temporary ARB therapy affects these changes.

III. Project title: Circadian Intraocular Pressure, Blood Pressure, and Pulse Variations in Stable and Unstable Primary Open-Angle Glaucoma

Human subjects IRB approved project number (where applicable): IRB # being processed

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Patient-based research

Brief Description of Project:This project is designed to study the relationship between blood pressure and intraocular pressure in patients with glaucoma and hypertension. Patients will be admitted to the CRC for a 24hour blood pressure monitor and serial intraocular pressure measurements.

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