Medical Student Research Fellowship for Summer 2007

Mentor: Tawanda Gumbo, MD
Department: Medicine/Infectious Diseases
Room number: Y7.312
Mail Code: 9113
Phone number: 214-648 9914
E-mail: Tawanda.Gumbo@UTSouthwestern.edu
Project title: Pharmacodynamics of antimalaria drugs

Human subjects IRB approved project number (where applicable): NA

Animal subjects IRB approved project number (where applicable): NA

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects)

Basic and translational research

Brief Description of Project:
This project looks at growth of Plasmodium falciparum in the hollow fiber, and the emergence of resistance to chloroquine. The pharmacokinetics-pharmacodynamics of chloroquine linked to emergence of resistance in P falciparum will be identified, and translation of the results to the clinic made using mathematical modeling.

Previous Research Activities or Publications with Medical Students:
Pharmacodynamics of drug resistance to antituberculosis agents rifampin and isoniazid.

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