Medical Student Research Fellowship for Summer 2007

Mentor: Joachim Herz
Department: Molecular Genetics
Room number: L5.230
Mail Code: 9046
Phone number: 214 648 5633
E-mail: Joachim.herz@utsouthwestern.edu
Project title: Molecular Genetics of Lipoprotein Receptors

Human subjects IRB approved project number (where applicable):

Animal subjects IRB approved project number (where applicable):

Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) basic research

Brief Description of Project:

Anandita will use cell culture, transfection and protein biochemistry approaches to identify proteins that interact with members of the LDL receptor gene family. This is important to understand the mechanisms that govern developmental signaling pathways that are involved in the formation of the kidneys and the brain.

Previous Research Activities or Publications with Medical Students:

Astrid Rohlmann, Michael Gotthardt, Thomas E. Willnow, Robert E. Hammer and Joachim Herz
Sustained Somatic Gene Inactivation By Viral Transfer of Cre Recombinase.
Nature Biotechnology 14, 1562-1565 (1996)

Astrid Rohlmann, Michael Gotthardt, Robert E. Hammer, and Joachim Herz
Inducible Inactivation of Hepatic LRP Gene By Cre-Mediated Recombination Confirms Role of LRP in Clearance of Chylomicron Remnants.
J. Clin. Invest. 101, 689-695 (1998)

Michael Gotthardt, Marion Trommsdorff, Matthew F. Nevitt, John Shelton, James A. Richardson, Walter Stockinger, Johannes Nimpf, and Joachim Herz
Interactions of the low density lipoprotein (LDL) receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
J. Biol. Chem. 275, 25616-25624 (2000)

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