Medical Student Research Fellowship for Summer 2009
Mentor: Dr. Philippe Zimmern & Dr. Robert Eberhart
Room number: G8.248
Mail Code: 9130
Phone number: 82052
E-mail: email@example.com & firstname.lastname@example.org
Project title: Biomechanical Properties of Prolapsed Anterior Vaginal Wall
Human subjects IRB approved project number (where applicable): 0402-222
Animal subjects IRB approved project number (where applicable):
Project Type (patient-based research, animal-based research, or basic research;
this characterization is only to permit a general classification for grouping
similar types of projects)
Brief Description of Project:
This project, started last summer, is still ongoing and continues to assess the unique biomechanical properties of human vaginal wall tissues of patients with advanced stage 3 and 4 vaginal prolapse and age-comparable controls (no prolapse). Intra-operative anterior vaginal wall tissue elastic properties are measured in vivo with the commercially available "Cutometer" device; then fresh anterior vaginal tissue harvested in the OR during prolapse repair or radical cystectomy (control) is immediately transported with different degrees of hydration to the biomechanical lab for measurement by the uniaxial tensile machine (Instron). Comparative assessment of in-vivo and ex-vivo vaginal wall tissue properties is obtained. In addition, the data is being used for finite element modeling of the anterior vaginal wall towards the dual goals of:1) understanding the deformation of this aged tissue under physiological loading; 2) developing engineered tissue reinforcement or replacement.
Previous Research Activities or Publications with Medical Students:
Elizabeth Mosier, Victor Lin, Philippe Zimmern. Extracellular matrix expression of human prolapsed vaginal wall. Submitted to NeuroUrology and Urodynamics, February 2009.
Elizabeth Mosier, Rashel Haverkorn, Philippe Zimmern. Long-term durability of Collagen for stress urinary incontinence. Presented at the Society of Female Urology and Urodynamics meeting. February 2009. Submitted to British Journal of Urology, March 2009.