Medical Student Research Fellowship for Summer 2009
Mentor: Jane Johnson
Room number: NA4.146
Mail Code: 9111
Phone number: 214-648-1870
Project title: Embryonic Neural Tube to Adult Brain: Mapping Neural Progenitor Fates
Human subjects IRB approved project number (where applicable): N/A
Animal subjects IRB approved project number (where applicable): 0603-06-03-1
Project Type: basic research
Brief Description of Project:
Neurog1 is a bHLH transcription factor essential during embryonic development for neuronal differentiation and specification in subsets of neurons in the central and peripheral nervous systems. Because expression of this regulatory factor is transient, the full complement of lineages arising from Neurog1 progenitor cells is not known. We have generated mouse models that allow in vivo genetic fate mapping. Tissue has been collected and initial data obtained that demonstrate complex contribution of Neurog1 lineages throughout the brain. This project is suited for an individual with interest in neuroanatomy who can identify these lineages and complete this study. It is anticipated that the student will write up this study and submit the manuscript for publication.
Previous Research Activities or Publications with Medical Students:
I have not mentored a medical student in a summer fellowship but I have mentored numerous individuals from high school students to undergraduates in summer fellowships. I also have mentored multiple students in their graduate training including MSTPs. Dr. J. Battiste who is now a neurology resident is an example of one such student. One of his publications is also a good example of the technology being used in the proposed project.
Battiste, J., Helms, A. W., Kim, E. J., Savage, T. K., Lagace, D. C., Mandyam, C. D., Eisch, A. J., Miyoshi, G., and Johnson, J. E. (2007) Ascl1 defines sequentially generated lineage restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 134, 285-293.