Medical Student Research Fellowship for Summer 2010

Mentor: Dr. Adebola Adesanya
Department: Anesthesiology
Room number:
a) Mail Code: 9068
Phone number: (214) 590-7243
E-mail: adebola.adesanya@utsouthwestern.edu
Project title: Metformin Continuation versus Interruption in type 2 Diabetes Patients Undergoing Ambulatory Surgery

Human subjects IRB approved project number: 032010-079
Date approved: April 9, 2010

Project Type

patient-based research

Brief Description of Project:

The purpose of this project is two fold. The first is to compare preoperative, intraoperative and postoperative blood glucose level in type 2 diabetic patients continuing or interrupting metformin treatment in the perioperative period. The second is to determine if continuing metformin treatment results in detectable lactic acidosis. To answer the questions that this study presents, demographic information from medical records will be collected; preoperative, intraoperative (hourly) and postoperative capillary blood glucose levels will be measured; and point of care lactic acid level will also recorded before surgery and in the post anesthesia recovery. We hypothesize that uninterrupted treatment with metformin in type 2 diabetic mellitus patients undergoing ambulatory surgery will not result in intraoperative and postoperative hypoglycemia (defined as blood glucose < 70mg/dl) compared to patients withholding metformin treatment on the day of surgery.

Previous Research Activities or Publications with Medical Students:

2008 - Vincent Olorunnisomo
2008 - John Chua Tuan
Effect of heart rate and tidal volume changes on systolic blood pressure variation in postoperative cardiac surgery patients.
Vincent Olorunnisomo, BS, John Chua-Tuan, BS, Jeffrey Drees, MD* and Adebola Adesanya, MBBS. American College of Chest Physicians. 2008.