Medical Student Research Fellowship for Summer 2010
Mentor: Pradeep P.A. Mammen, MD
Department: Cardiology/Internal Medicine
Room number: NB10.228
Mail Code: MC 9047
Phone number: 214-648-4994
Project title: Role of Hemoproteins in Modulating Oxidative Stress in Heart Failure
Human subjects IRB approved project number (where applicable):Not Applicable
Animal subjects IRB approved project number (where applicable): 1078-07-01-1, 1078-07-02-1, and 2009-0216.
Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Animal-based and basic research.
Brief Description of Project:
My clinical and scientific interests revolve around the treatment and management of patients with heart failure and the molecular mechanisms underlying this clinical entity. I run a molecular cardiology laboratory that is focused on enhancing our understanding of how regulation of the metabolic and redox states of myocytes can be modulated to serve as potential therapeutic targets for various cardiac and skeletal myopathies. Ultimately, the ability to selectively regulate the metabolic and redox states within cardiomyocytes as well as cardiac progenitor cells may provide opportunities for the development of novel therapeutic approaches to the treatment of patients with heart failure.
Specifically, there are two ongoing research projects that may be of interest to a medical student for a summer project and they are as follows:
1. Investigate the mechanism by which myoglobin modulates physiology hypertrophy.
2. Investigate the mechanism by which cytoglobin modulates pathologic cardiac remodeling.
Previous Research Activities or Publications with Medical Students:
Bryan A. Reyes (Summer of 2008)
Bryan Reyes is currently a medical student at UT Southwestern Medical Center. During the Summer of 2008, he worked in my laboratory investigating the role of cytoglobin during myocyte differentiation/proliferation.
Adrian Salinas (Summer of 2008)
Adrian Salinas is currently a medical student at UT Southwestern Medical Center. During the Summer of 2008, he worked in my laboratory investigating the role of myoglobin during cardiac growth.
Sudhir Thotakura (2008)
Sudhir Thotakura is currently a medical student at Texas Tech School of Medicine. In 2008, he worked in my laboratory for 6 months prior to entering medical school. His work in the laboratory focused on investigating the role of myoglobin on cardiac growth.
Singh, S. R. Chirumamilla, D. Canseco, S. Thotakura, M. Jeffrey, R.D. Gerard, Z. Yan, M.H. Drazner, C. Malloy, B.A. Rothermel, J.A. Hill and P.P.A. Mammen. Myoglobin overexpressing hearts develop physiologic hypertrophy and have a blunted response to mechanical loading. In preparation.
Amanda McGrath (2002-2004)
Amanda McGrath was an undergraduate student from the University of North Texas, who worked with me to initially characterize the gene expression pattern of cytoglobin. She worked in the laboratory at nights and weekends over a 2 year time period. Her hard work resulted in an authorship on a recent manuscript that was published in 2006.
Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry. Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain. Journal of Histochemistry & Cytochemistry 2006; 54(12): 1349-1361.