Medical Student Research Fellowship for Summer 2012
Mentor: Dr. Philippe Zimmern
Room number: J08.122
Mail Code: 9110
Phone number: 214-648-9397
Project title: Relevance of a newly designed cutometer-like probe for routine vaginal examination in the outpatient setting.
Human subjects IRB approved project number (where applicable):
Animal subjects IRB approved project number (where applicable):
Project Type: Patient-based research
Brief Description of Project:
This proposal is to study this new vaginal version of the BTC-2000 in the office setting in patients scheduled for POP repair vaginally.
Caitlin will introduce the new device to patients and obtain measurements using the device. She will collect data on ease of use, patient acceptability (questionnaire), and accuracy and reproducibility of the biomechanical parameters extracted from the collected data (laxity, elasticity, elastic deformation, and Young’s modulus). Additionally, she will compare the data collected in the office setting to data obtained in the operating room under anesthesia, and with follow-up data obtained after surgery.
Such a device would, for the first time, allow a direct in-vivo measurement of vaginal wall tissue properties. This could influence a myriad of common vaginal interventions, from pelvic floor therapy to reconstructive surgery. Like the thermometer to determine how sick a patient is, this device would serve as a fantastic resource for clinicians and researchers interested in the management of POP, an embarrassing and costly affliction which greatly affects the quality of life of millions of women.
Previous Research Activities or Publications with Medical Students:
Mosier E, Lin VK, Zimmern P. Extracellular matrix expression of human prolapsed vaginal wall. Neurourol Urodyn. 29(4):582-586, 2010.
Murray S, Schlomer BJ, Jerome R, Zimmern PE: Secondary autologous fasica slings fare more poorly than primary slings.
Mosier E, Jerome R, Xie X-J, Chuong C, Yan J, Eberhart R, Zimmern P: In vivo (Cutometer©) measurement of anterior vaginal wall biomechanical properties in prolapse patients undergoing surgical repair. Submitted to Neurourology and Urodynamics.
Mosier E, Haverkorn RM, Zimmern PE. Abstract #1538: 3-D ultrasound assessment of collagen volume stability and durability over time in incontinent women. AUA Annual Meeting, April 24 ¨C 28, 2009, Chicago, Illinois
Chuong C, Towns R, Eberhart R, Mosier E, Zimmern P. Development of a biomechanical finite element model to predict prolapsed anterior vaginal wall compartment properties. Podium presentation ICS meeting 8/22-27/2010, Toronto.
Adam N. Romman, Feras Alhalabi, and Philippe E. Zimmern. Urethral dilation under anesthesia in women
Jerome R, Murray S, Zimmern P; The dark side of prophylactic suburethral tape placement. Poster, SUFU Annual meeting, St. Petersburg, Florida. 2010.
Schomer B, Jerome R, Murray S, Haverkorn R, Zimmern P. Secondary autologous fascia slings fare more poorly than primary slings. Poster. SUFU Annual meeting, St. Petersburg, Florida, 2010.
Mosier E, Jerome R, Chuong C, Eberhart R, Zimmern P. In vivo measurement of the anterior vaginal wall biomechanical properties in prolapse patients undergoing surgical repair. Podium presentation, SUFU Annual meeting, St. Petersburg, Florida, 2010.