Medical Student Research Fellowship for Summer 2012

Mentor:  Babatunde Ogunnaike, MD      
Department: Anesthesiology & Pain Management     
Room number: PMH 2nd Floor
Mail Code: 9068      
Phone number: 214-590-8536
E-mail:           babatunde.ogunnaike@utsouthwestern.edu   
Project title:   Identification of the Optimal Transthoracic Defibrillation Energy Parameters for Post-Cardiac Arrest Resuscitation in Obese Patients

Human subjects IRB approved project number (where applicable):
STU 062011-017

Project Type:    Retrospective Chart Review Research Study

Brief Description of Project.

The aim of the study is to determine the Optimal Transthoracic Defibrillation Energy Parameters for Post-Cardiac Arrest Resuscitation in Obese Patients.

Defibrillation is recognized as the only effective means for prevention of sudden cardiac death. Defibrillations success and failure is largely trial and error; varying depths of ventricles unique to markedly overweight patients only further exacerbate this subjectivity. Therefore, retrospectively, we hope to determine optimal defibrillation parameters in obese patients during post-cardiac arrest resuscitation by establishing the correlation between obesity and amount of energy necessary/used successfully for resuscitation.

The study is including chart reviews of four hundred obese men and women between the ages of 18 and 80 (obese being defined as body mass index [BMI] of 30 kg/m2) that were admitted to/or treated at Parkland Hospital with transthoracic defibrillation for cardiac arrest.

Patient charts will be reviewed to collect necessary data and to determine eligibility for the study. Parameters to be considered include age; sex; weight and height; diagnosis; treatment modalities while in the hospital (medical, surgical, etc.); cause of cardiac arrest (if known); CPR modalities (if recorded); energy employed during defibrillation; number of times defibrillated, and interval between defibrillation attempts. Final disposition will be categorized as (1) survived, (2) survived with end organ damage, and (3) unsuccessful defibrillation and/or death.
Inclusion Criteria of the subjects: The subject population will include 400 obese (defined by a BMI=30) men and women age 18-80 who were admitted to/or treated at Parkland Hospital for Cardiac arrest, and defibrillated.
Exclusion Criteria of the subjects: Those patients that meet the criteria but did not experience cardiac arrest, or that were not defibrillated.

This is a retrospective study. The charts are collecting through a National database.

Student can actively participate data gathering and evaluation of the data in that study.

 

Previous Research Activities or Publications with Medical Students:

  1. White PF, Sacan O, Tufanogullari, Eng M, Nuangchamnong N, Ogunnaike B. Effect of short-term postoperative celecoxib administration on patient outcome after outpatient laparoscopic surgery.  Can J Anesth 2007 (in press)
  2. Recart A, Gasanova I, White PF, Thomas T, Ogunnaike B, Hamza M, Wang A: Effect of cerebral monitoring on recovery after general anesthesia: comparison of AEP vs BIS devices vs standard clinical practice.  Anesth Analg 2003; 97: 1667-74.
  3. Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Berrisford SB, Wakefield CA, Issioui T, Jones SB, Jones DB,: Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting.  Anesthesiology 2002: 97:1387-92.
  4. White PF, Tang J, Hamza MA, Ogunnaike B, Lo M, Wender RH, Naruse R, Sloninsky A, Kariger R.  The use of oral granisetron versus intravenous ondansetron for antiemetic prophylaxis in patients undergoing laparoscopic surgery: the effect on emetic symptoms and quality of recovery.  Anesth Analg 2006; 102: 1387-93.
  5. Yu Hong.  Abstract presented on Obesity and Defibrillation
  6. Rebecca Yarborough, Mentor for summer 2011