Mentor: Emmanouil S. Brilakis, MD, PhD
Department: Cardiology
Room number: 5B-670
Mail Code: 111A
Phone number: 214-857-1547
E-mail: esbrilakis@yahoo.com
Project title: The SOS (Stenting Of Saphenous vein grafts) multicenter
randomized controlled trial of a paclitaxel-eluting vs. a similar bare metal
stent in saphenous vein graft lesions.
Human subjects IRB approved project number (where applicable): 05-026
Animal subjects IRB approved project number (where applicable):
Project Type patient-based research
Brief Description of Project:
The SOS is the first multicenter, randomized-controlled trial of drug-eluting
stents in saphenous vein grafts. The study is comparing the Taxus paclitaxel-eluting
stent with a similar bare metal stent in saphenous vein graft lesions. The angiographic
results of the study were presented in October 2008 and showed significant reduction
of in-stent restenosis in the drug-eluting stent arm.
Several substudies of SOS are being planned including:
(a) presentation of in-stent restenosis in SVGs
(b) intravascular ultrasound analysis of the SVGs
(c) use of embolic protection devices in SOS
(d) long-term follow-up of the SOS trial patients
(e) assessment of a newer drug-eluting stents (Xience and Endeavor) in saphenous
vein graft lesions.
In addition to the SOS multiple other clinical projects are currently active, examining the incidence and types of percutaneous coronary intervention complications, the effect of smokeless tobacco on coronary arteries, perioperative management of drug-eluting stents, description of novel interventional procedural techniques, etc.
Previous Research Activities or Publications with Housestaff:
1. Brilakis ES, Lichtenwalter C, de Lemos JA, Roesle M, Obel O, Haagen D, Saeed B, Gadiparthi C, Bissett JK, Voudris VV, Karyofillis P, Kar B, Rossen J, Fasseas P, Berger PB, Banerjee S. A Randomized-Controlled Trial Of A Paclitaxel-Eluting Stent vs. A Similar Bare Metal Stent In Saphenous Vein Graft Lesions. The SOS (Stenting Of Saphenous Vein Grafts) Trial. J Am Coll Cardiol:in press
2. Varghese, I, Samuel J, Banerjee S, Brilakis ES. Comparison of Percutaneous Coronary Intervention in Native Coronary Arteries vs. Bypass Grafts in Prior Coronary Artery Bypass Graft Surgery Patients. Cardiovasc Revasc Med; in press
3. Dimas B, Lindsey JB, Banerjee S, Brilakis ES. ST-segment Elevation Acute Myocardial infarction Due To Severe Hypotension and Proximal Left Subclavian Artery Stenosis in a Prior Coronary Artery Bypass Graft Patient. Cardiovasc Revasc Med; in press
4. Luna M, Banerjee S, Brilakis ES. Closure of a Coexisting Ostium Secundum Atrial Septal Defect and Patent Foramen Ovale Using a Single Amplatzer Patent Foramen Ovale Occluder Device. Cardiovasc Revasc Med; in press
5. Boatman D, Saeed B, Varghese I, Peters CT, Daye J, Peters Haider A, Roesle M, Banerjee S, Brilakis ES. Prior coronary artery bypass graft surgery patients undergoing diagnostic coronary angiography have multiple uncontrolled coronary artery disease risk factors and high risk for cardiovascular events. Heart Vessels; in press
6. Prasad A, Prasad A, Varghese I, Roesle M, Banerjee S, Brilakis ES. Prevalence and treatment of proximal left subclavian artery stenosis in patients referred for coronary artery bypass surgery. Int J Cardiol; in press
7. Banerjee S, Varthese C, Samuel J, Weideman RA, Little BB, Kelly KC, Rao SV, Reily RF, Brilakis ES. Prolonged Clopidogrel Use Following Percutaneous Coronary Intervention is Associated with Lower Mortality. Am J Cardiol; in press
8. Daye J, Boatman D, Peters C, Varghese I, Haider A, Roesle M, Jessen ME, DiMaio JM, Banerjee S, Brilakis ES. Perioperative Risk of Patients Undergoing Noncardiac Surgery After Coronary Artery Bypass Surgery. J Investig Med 2008;56:878-881
9. Varghese I, Ummer A, Roesle M, Banerjee S, Brilakis ES. Recurrent late drug-eluting stent thrombosis upon discontinuation of antiplatelet therapy. Cardiovasc Revasc Med 2008;9:179-181
10. Brilakis ES, Saeed, B, Banerjee S. Use of Drug-Eluting Stents in Saphenous Vein Aortocoronary Bypass Graft Lesions: a Critical Appraisal. J Interv Cardiol 2008;21:151-157
11. Varghese I, Boatman DM, Peters CT, Daye J, Haider A, Roesle M, Banerjee S, Brilakis ES. Impact on Contrast, Fluoroscopy, and Catheter Utilization From Knowing the Coronary Artery Bypass Graft Anatomy Before Diagnostic Coronary Angiography. Am J Cardiol 2008; 101:1729-1732
12. Prasad A, Cipher DJ, Prasad A, Mohandas A, Roesle M, Brilakis ES, Banerjee S. Reproducibility of Intravascular Ultrasound Virtual Histology Analysis. Cardiovasc Revasc Med 2008;9:71-77
13. Haider A, Banerjee S, Brilakis ES. Acute Pulmonary Edema due to Pacemaker-Induced Mitral Regurgitation. J Invasive Cardiol; 2008;20:E84
14. Lindsey JB, Brilakis ES, Banerjee S. Extrinsic Compression of the Left Main Coronary Artery Treated with Percutaneous Coronary Intervention. A Case Report and Review of the Literature. Cardiovasc Revasc Med 2008;9:47-51
15. Prasad A, Compton PA, Prasad A, Roesle M, Makke L, Rogers S, Banerjee S, Brilakis ES. Incidence and treatment of arterial access dissections occurring during cardiac catheterization. J Interv Cardiol 2008;21:61-66
16. Lindsey JB, Banerjee S, Brilakis ES. Two "buddies" may be better than one: use of two buddy wires to expand an under-expanded left main coronary stent. J Invasive Cardiol 2007;19:E355-358
17. Iturbe JM, Banerjee S, Brilakis ES. Exertional dyspnea due to spontaneous coronary artery dissection in a 55-year-man. Heart 2007;93:1212