Mentor: Robert Toto, Jula Inrig
Department: Medicine - Nephrology
Room number:
Mail Code: 8856
Phone number: 214-648-2516
E-mail: jula.inrig@utsouthwestern.edu
Project title: Blood Pressure, endothelial cell dysfunction and outcomes
in dialysis patients
Human subjects IRB approved project number (where applicable): 102008-042
Animal subjects IRB approved project number (where applicable): n/a
Project Type (patient-based research, animal-based research, or basic research; this characterization is only to permit a general classification for grouping similar types of projects) Patient based
Brief Description of Project:
The specific aims of this project are as follows:
1. To demonstrate in a national hemodialysis cohort that increasing blood pressure
during hemodialysis is associated with increased cardiovascular morbidity and
mortality;
2. Recruit 50 maintenance hemodialysis patients including 25 with intradialytic
hypertension and 25 controls to determine the relationship between intradialytic
hypertension and a) endothelial cell function measure by endothelial progenitor
cells and flow mediated dilation; b) vascular compliance measure by pulse wave
velocity; and c) time-averaged blood pressure burden measured by 44-hour interdialytic
ambulatory blood pressure
3. Conduct a pilot study in 25 maintenance hemodialysis patients with intradialytic
hypertension to determine whether chronic administration of carvedilol at a
dose of 50 mg daily will improve surrogate markers of cardiovascular outcomes
including: endothelial progenitor cells, flow mediated vasodilation, pulse wave
velocity, and blood pressure.
Previous Research Activities or Publications of J.I. with Housestaff:
This is a representative list of publications during my faculty time at Duke. I (J.I.) transferred to UTS 9/1/2008.
1. Inrig JK, Reed S, Szczech LA, Engemann J, Friedman JY, Corey RC, Schulman
K, Reller LB, Fowler VG. Relationship between Clinical Outcomes and Vascular
Access Type among Hemodialysis Patients with Staphylococcus aureus Bacteremia
Clin J Am Soc Nephrol, 1: 518-524, 2006.
2. Inrig JK, Sun JL, Yang Q, Briley LP, Szczech LA. Mortality by Dialysis Modality
among ESRD Patients Awaiting Renal Transplantation. Clin J Am Soc Nephrol, 1:774-779,
2006.
3. Stryjewski E, Szczech LA, Benjamin DK, Inrig JK, Kanafani ZA, Engemann JJ,
Chu VH, Reller LB, Corey GR, Fowler, VG. Use of Vancomycin or First Generation
Cephalosporins in the Treatment of Hemodialysis-dependent Patients with Methicillin-Susceptible
Staphylococcus aureus Bacteremia. CID, 44:190-196,2007.
4. Inrig JK, Patel UD, Gillespie BS, Hasselblad V, Himmelfarb J, Reddan D, Lindsay
RM, Winchester JF, Stivelman J, Toto R, Szczech LA. Relationship between Interdialytic
Weight Gain and Blood Pressure in Hemodialysis Patients. Am J Kidney Disease,
50(1):108-118.e1-4, 2007.
5. Inrig JK, Oddone EZ, Hasselblad V, Gillespie B, Patel UD, Reddan D, Toto
R, Himmelfarb J, Winchester JF, Stivelman J, Lindsay RM, Szczech LA. Association
of Intradialytic Blood Pressure Changes with Hospitalization and Mortality Rates
in Prevalent ESRD Patients. Kidney International, 71:454-561, 2007.
6. Inrig JK, Gillepie BS, Briley LP, Patel UD, She L, Easton JD, Topol E, Szczech
LA. Risk of Cardiovascular Outcomes among Subjects with Atherosclerotic Cardiovascular
Disease and Greater than Normal estimated Glomerular Filtration Rate. Clin J
Am Soc Nephrol, 2(6):1215-22, 2007
7. Inrig JK, Patel UD, Briley LP, She L, Gillespie B, Easton JD, Topol E, Szczech
LA. Mortality, Kidney Disease, and Cardiac Procedures following Acute Coronary
Syndrome. Nephrology Dialysis Transplantation, 23:934-940, 2008
8. Szczech LA, Barnhart H, Inrig JK, Reddan D, Sapp S, Califf RM, Patel UD,
Singh AJ. Secondary analysis of the CHOIR trial: epoetin- dose and achieved
hemoglobin outcomes. Kidney International; 74:791-798, 2008
9. Ellis MJ, Parikh CR, Inrig JK, Kambay M, Patel UD. Chronic Kidney Disease
after Hematopoietic Cell Transplantation: a Systematic Review. American Journal
Transplantation;8:2378-2390, 2008.
10. Li Y, Friedman JY, O'Neal BF, Hohenboken MJ, Griffiths RI, Stryjewski ME,
Middleton JP, Schulman KA, Inrig JK, Fowler VF, Reed SD. Outcomes of Staphylococcus
aureus infection in Hemodialysis-Dependent Patients. cJASN, in press