Member of the Cell Regulation Graduate Program
Professor, Internal Medicine, Endocrinology and Metabolism Division
E-mail: michael.mcphaul@utsouthwestern.edu
Page Index
List of Publications: Selected Comprehensive
Listing of Previous Fellows/Students
Availability of Positions to support Postdoctoral Fellows or Students
The focus of research in my laboratory
has been to understand how the male hormones, testosterone and
5-alpha-dihydrotestosterone exert their effects during embryogenesis, in
the adult, and in disease states. These interests are focused into the following
broad areas:
1) Androgen resistance: We have defined
a large number of mutations in the androgen receptor (AR) gene that cause
androgen resistance. It is clear that most are caused by amino acid substitutions
in the hormone-binding domain of the receptor. Current work is focused on
understanding how these substitutions interfere with AR function at the molecular
level.
2) Genetic control of androgen receptor
expression: AR expression varies from tissue to tissue and at different times
during development. The basis for those controls is being defined using cell
culture and transgenic models.
3) The androgen receptor in human prostate
cancer: The clearcut relationship between prognosis and estrogen receptor
expression in breast cancer does not hold true in all patient groups for
AR expression and prostatic cancer. It is clear, however, that AR expression
does vary in selected prostate cancers. We are attempting to define the
implications of these changes and the mechanisms by which prostate cancers
progress to a state in which androgens are no longer required for growth.
4) Androgen metabolism and its effects
on androgen action: Testosterone is the principal circulating androgen in
mammals. It can undergo 5-alpha-reduction to for 5-alpha-dihydrotestosterone,
a more potent androgen, or aromatization to form estradiol, a potent estrogen.
Our work in this area is focused on a) characterizing genes that are
differentially regulated by testosterone and dihydrotestosterone and b) defining
the mechanisms controlling aromatase gene expression in rat gonadal cells.
Student: Yes. Members of the Cell Regulation or
other graduate programs within the Division of Cell and Molecular Biology,
members of the Medical Scientist Training Program.
Ph.D. Postdoctoral Fellowship Positions: Yes. Support
may be available through the Endocrinology and Metabolism training grant.
M.D. Postdoctoral Fellowship Positions: Yes. Support
may be available through the Endocrinology and Metabolism training grant.
Former Students
1. Kyba EP, Hudson CW, McPhaul MJ, Meredith AM 1977 Polyphosphino macrocyclic ligand systems. J Am Chem Soc 99:8053-8054
2. Krieger M, McPhaul MJ, Goldstein JL, Brown MS 1979 Replacement of neutral lipids of low density lipoprotein with esters of long chain unsaturated fatty acids. J Biol Chem 254:3845-3853
3. Schneider WJ, Basu SK, McPhaul MJ, Goldstein JL, Brown MS 1979 Solubilization of the low density lipoprotein receptor. Proc Natl Acad Sci USA 76:5577-5581
4. Kyba EP, John AM, Brown SB, Hudson CW, McPhaul MJ, Harding A, Larsen K, Niedswiecki S, Davis RE 1980 Triligating in membered rings containing tertphosphino sites, synthesis and structure. J Am Chem Soc 102:139
5. Kyba EP, Davis RE, Hudson CW, John AM, Brown SB, McPhaul MJ, Liu L-K, Glover AC 1981 Tetra dentate 14-membered tertphosphino containing macrocycles. J Amer Chem Soc 103:3868-3875
6. Firestone RA, Pisano JM, Falck JR, McPhaul MJ, Krieger M 1984 Selective delivery of cytotoxic compounds to cells by the LDL pathway. J Med Chem 27:1037-1043
7. McPhaul MJ, Berg P 1986 Formation of functional asialoglycoprotein receptor after transfection with cDNAs encoding the receptor proteins. Proc Natl Acad Sci USA 83:8863-8867
8. McPhaul MJ, Berg P 1987 Identification and characterization of cDNA clones encoding two homologous proteins that are part of the asialoglycoprotein receptor. Mol Cell Biol 7:1841-1847
9. McPhaul MJ, Noble JF, Simpson ER, Mendelson CR, Wilson JD 1988 The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen. J Biol Chem 263:16358-16363
10. Corbin CJ, Graham-Lorence S, McPhaul MJ, Mason JI, Mendelson CR, Simpson ER 1988 Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci USA 85:8948-8952
11. McPhaul MJ, Noble JF, Matsumine H, Wilson JD 1988 Cloning and expression of the chicken ovary aromatase P-450: Expression of mRNA in tissues of the Sebright and Leghorn chicken. Trans Assoc Am Physicians 101:219-225
12. Tilley WD, Marcelli M, Wilson JD, McPhaul MJ 1989 Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci USA 86:327-331
13. George FW, Matsumine H, McPhaul MJ, Somes RG Jr, Wilson JD 1990 Inheritance of the henny feathering trait in the Golden Campine chicken: Evidence for allelism with the gene that causes henny feathering in the Sebright Bantam. J Hered 81:107-110
14. Tilley WD, Marcelli M, McPhaul MJ 1990 Recent studies of the androgen receptor: New insights into old questions. Mol Cell Endocrinol 68:C7-C10
15. Marcelli M, Tilley WD, Wilson CM, Wilson JD, Griffin JE, McPhaul MJ 1990 A single nucleotide substitution introduces a premature termination codon into the androgen receptor gene of a patient with receptor-negative androgen resistance. J Clin Invest 85:1522-1528
16. Lephart ED, Peterson KG, Noble JF, George FW, McPhaul MJ 1990 The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line. Mol Cell Endocrinol 70:31-40
17. Husmann DA, Wilson CM, McPhaul MJ, Tilley WD, Wilson JD 1990 Antipeptide antibodies to two distinct regions of the androgen receptor localize the receptor protein to the nuclei of target cells in the rat and human prostate. Endocrinology 126:2359-2368
18. Matsumine H, Wilson JD, McPhaul MJ 1990 Sebright and Campine chickens express aromatase P-450 mRNA inappropriately in extraglandular tissues and in skin fibroblasts. Mol Endocrinol 4:905-911
19. Marcelli M, Tilley WD, Wilson CM, Griffin JE, Wilson JD, McPhaul MJ 1990 Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: Premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Mol Endocrinol 4:1105-1116
20. Woeltje KF, Esser V, Weis BC, Sen A, Cox WF, McPhaul MJ, Slaughter CA, Foster DW, McGarry JD 1990 Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II. J Biol Chem 265:10720-10725
21. Tilley WD, Marcelli M, McPhaul MJ 1990 Expression of the human androgen receptor gene utilizes a common promoter in diverse human tissues and cell lines. J Biol Chem 265:13776-13781
22. Tilley WD, Wilson CM, Marcelli M, McPhaul MJ 1990 Androgen receptor gene expression in human prostate carcinoma cell lines. Cancer Res 50:5382-5386
23. Husmann DA, McPhaul MJ 1991 Localization of the androgen receptor in the developing rat gubernaculum. Endocrinology 128:383-387
24. Tereba A, McPhaul MJ, Wilson JD 1991 The gene for aromatase (P450arom) in the chicken is located on the long arm of chromosome 1. J Hered 82:80-81
25. Marcelli M, Zoppi S, Grino PB, Griffin JE, Wilson JD, McPhaul MJ 1991 A mutation in the DNA-binding domain of the androgen receptor gene causes complete testicular feminization in a patient with receptor-positive androgen resistance. J Clin Invest 87:1123-1126
26. Husmann DA, McPhaul MJ, Wilson JD 1991 Androgen receptor expression in the developing rat prostate is not altered by castration, flutamide, or suppression of the adrenal axis. Endocrinology 128:1902-1906
27. Krongrad A, Wilson CM, Wilson JD, Allman DR, McPhaul MJ 1991 Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells. Mol Cell Endocrinol 76:79-88
28. McPhaul MJ, Marcelli M, Tilley WD, Griffin JE, Isidro-Guiterrez RF, Wilson JD 1991 Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen receptor and responsive to high-dose androgen therapy. J Clin Invest 87:1413-1421
29. Doody KJ, Lephart ED, Stirling D, Lorence MC, Magness RR, McPhaul MJ, Simpson ER 1991 Expression of mRNA species encoding steroidogenic enzymes in the rat ovary. J Mol Endocrinol 6:153-162
30. Takane KK, Husmann DA, McPhaul MJ, Wilson JD 1991 Androgen receptor levels in the rat penis are controlled differently in distinctive cell types. Endocrinology 128:2234-2238
31. Marcelli M, Tilley WD, Zoppi S, Griffin JE, Wilson JD, McPhaul MJ 1991 Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg-Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function. J Clin Endocrinol Metab 73:318-325
32. Takane KK, Wilson JD, McPhaul MJ 1991 Decreased levels of the androgen receptor in the mature rat phallus are associated with decreased levels of androgen receptor messenger ribonucleic acid. Endocrinology 129:1093-1100
33. Sanghera M, Simpson ER, McPhaul MJ, Kozlowski G, Conley AJ, Lephart ED 1991 Immunocytochemical distribution of aromatase cytochrome P-450 in the rat brain using synthetic peptide-generated polyclonal antibodies. Endocrinology 129:2834-2844
34. Husmann DA, McPhaul MJ 1991 Time specific androgen blockade with flutamide inhibits testicular descent in the rat. Endocrinology 129:1409-1416
35. Husmann DA, Wilson CM, Wilson JD, Tilley WD, McPhaul MJ 1991 Structure and expression of the androgen receptor gene in normal tissues and in prostate carcinoma cell lines. In: Karr JP, Coffey DS, Smith RG, Tindall DJ (eds), Molecular and Cellular Biology of Prostate Cancer, Plenum Press, New York, pp 223-227
36. McPhaul MJ, Marcelli M, Tilley WD, Griffin JE, Wilson JD 1991 Androgen resistance caused by mutations in the androgen receptor gene. FASEB J 5:2910-2915
37. Matsumine H, Herbst MA, Ou S-HI, Wilson JD, McPhaul MJ 1991 Aromatase mRNA in the extragonadal tissues of chickens with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. Functional organization of the Sebright, Leghorn, and Campine aromatase genes. J Biol Chem 266:19900-19907
38. McPhaul MJ, Matsumine H, Herbst MA, Wilson JD 1991 Aromatase expression in extragonadal tissues of the Sebright chicken is controlled by a retroviral promoter. Trans Assoc Am Physicians 104:141-149
39. Roehrborn CG, Zoppi S, Gruber JA, Wilson CM, McPhaul MJ 1992 Expression and characterization of full-length and partial human androgen receptor fusion proteins. Implications for the production and applications of soluble steroid receptors in Escherichia coli. Mol Cell Endocrinol 84:1-14
40. Leachman SA, Gallagher PJ, Herring BP, McPhaul MJ, Stull JT 1992 Biochemical properties of chimeric skeletal and smooth muscle myosin light chain kinases. J Biol Chem 267:4930-4938
41. Zoppi S, Marcelli M, Deslypere J-P, Griffin JE, Wilson JD, McPhaul MJ 1992 Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance. Mol Endocrinol 6:409-415
42. Marcelli M, Tilley WD, Zoppi S, Griffin JE, Wilson JD, McPhaul MJ 1992 Molecular basis of androgen resistance. J Endocrinol Invest 15:149-159
43. Lephart ED, Doody KJ, McPhaul MJ, Simpson ER 1992 Inverse relationship between ovarian aromatase cytochrome P-450 and 5-reductase enzyme activities and mRNA levels during the estrous cycle in the rat. J Steroid Biochem Mol Biol 42:439-447
44. Lephart ED, Simpson ER, McPhaul MJ 1992 Ovarian aromatase cytochrome P-450 mRNA correlates with enzyme activity and serum estradiol levels in anestrous, pregnant and lactating rats. Mol Cell Endocrinol 85:205-214
45. Deslypere J-P, Young M, Wilson JD, McPhaul MJ 1992 Testosterone and 5-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene. Mol Cell Endocrinol 88:15-22
46. Husmann DA, McPhaul MJ 1992 Reversal of flutamide-induced cryptorchidism by prenatal time-specific androgens. Endocrinology 131:1711-1715
47. McPhaul MJ, Marcelli M, Zoppi S, Wilson CM, Griffin JE, Wilson JD 1992 Mutations in the ligand-binding domain of the androgen receptor gene cluster in two regions of the gene. J Clin Invest 90:2097-2101
48. Wilson CM, Griffin JE, Wilson JD, Marcelli M, Zoppi S, McPhaul MJ 1992 Immunoreactive androgen receptor expression in patients with androgen resistance. J Clin Endocrinol Metab 75:1474-1478
49. Lephart ED, Simpson ER, McPhaul MJ, Kilgore MW, Wilson JD, Ojeda SR 1992 Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal development in the rat. Mol Brain Res 16:187-192
50. Hall RE, Tilley WD, McPhaul MJ, Sutherland RL 1992 Regulation of androgen receptor gene expression by steroids and retinoic acid in human breast-cancer cells. Int J Cancer 52:778-784
51. McPhaul MJ, Marcelli M, Zoppi S, Griffin JE, Wilson JD 1993 The spectrum of mutations in the androgen receptor gene that causes androgen resistance. J Clin Endocrinol Metab 76:17-23
52. Zoppi S, Wilson CM, Harbison MD, Griffin JE, Wilson JD, McPhaul MJ, Marcelli M 1993 Complete testicular feminization caused by an amino terminal truncation of the androgen receptor with downstream initiation. J Clin Invest 91:1105-1112
53. McPhaul MJ, Herbst MA, Matsumine H, Young M, Lephart ED 1993 Diverse mechanisms of control of aromatase gene expression. J Steroid Biochem Mol Biol 44:341-346
54. McPhaul MJ, Deslypere J-P, Allman DR, Gerard RD 1993 The adenovirus-mediated delivery of a reporter gene permits the assessment of androgen receptor function in genital skin fibroblast cultures. J Biol Chem 268:26063-26066
55. McCammon DK. Zhou P. Turney MK. McPhaul MJ. Kovacs WJ 1993 An androgenic affinity ligand covalently binds to cytosolic aldehyde dehydrogenase from human genital skin fibroblasts Mol Cell Endocrinol 91: 177-83.
56. McPhaul MJ 1993 Mutations in steroid hormone receptors causing clinical disease. In: Parker MG (ed), Steroid Hormone Action, Oxford University Press, New York, pp 186-208
57. Husmann DA, Boone TB, McPhaul MJ 1994 Flutamide-induced testicular undescent in the rat is associated with alterations in genitofemoral nerve morphology. J Urol 151:509-513
58. Wilson CM, McPhaul MJ 1994 A and B forms of the androgen receptor are present in human genital skin fibroblasts. Proc Natl Acad Sci USA 91:1234-1238
59. Abdelgadir SE, Resko JA, Ojeda SR, Lephart ED, McPhaul MJ, Roselli CE 1994 Androgens regulate aromatase cytochrome P450 messenger ribonucleic acid in rat brain. Endocrinology 135:395-401
60. Marcelli M, Zoppi S, Wilson CM, Griffin JE, McPhaul MJ 1994 Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex. J Clin Invest 94:1642-1650
61. Bentvelsen FM, McPhaul MJ, Wilson JD, George FW 1994 The androgen receptor of the urogenital tract of the fetal rat is regulated by androgen. Mol Cell Endocrinol 105:21-26
62. Lephart ED, Herbst MA, McPhaul MJ 1995 Characterization of aromatase cytochrome P-450 mRNA in rat perinatal brain, ovary, and a Leydig tumor cell line: Evidence for the existence of brain specific aromatase transcripts. Endocrine 3:25-31
63. McPhaul MJ 1995 Mutations in the androgen receptor gene that cause androgen resistance. In: Weintraub BD (ed), Molecular Endocrinology: Basic Concepts and Clinical Correlations, Raven Press, New York, pp 411-423
64. Griffin JE, McPhaul MJ, Russell DW, Wilson JD 1995 The androgen resistance syndromes: Steroid 5alpha-reductase 2 deficiency, testicular feminization, and related disorders. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds), The Metabolic and Molecular Bases of Inherited Disease, 7th ed, McGraw-Hill, New York, Vol II, Chap 95, pp 2967-2998
65. Krongrad A, Wilson JD, McPhaul MJ. 1995 Cloning and partial sequence of the rabbit androgen receptor: Expression in fetal urogenital tissues. J Androl 16:209-212
66. Bingham PM, Scott MO, Wang S, McPhaul MJ, Wilson EM, Garbern JY, Merry DE, Fischbeck FH. 1995 Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice. Nature Genet 9:191-196
67. Alléra A, Herbst MA, Griffin JE, Wilson JD, Schweikert H-U, McPhaul MJ 1995 Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias. J Clin Endocrinol Metab 80:2697-2699
68. Griffin JE, Wilson JD, McPhaul MJ 1995 The clinical and molecular spectrum of disorders of the androgen receptor. In: Hedon B, Bringer J, Mares P (eds), Fertility and Sterility: A Current Overview, Proceedings of the 15th World Congress on Fertility and Sterility, Montpellier, France, 17-22 September 1995, Parthenon Publishing, New York, pp 279-281
69. McPhaul MJ 1996 The androgen receptor and prostate cancer. In: Pasqualini JR, Katzenellenbogen BS (eds), Hormone-Dependent Cancer, Marcel Dekker, New York, pp 307-321
70. Cooper B, Gruber JA, McPhaul MJ 1996 Hormone-binding and solubility properties of fusion proteins containing the ligand-binding domain of the human androgen receptor J Steroid Biochem Mol Biol 57: 251-257
71. Takane KK, McPhaul MJ 1996 Functional analysis of the human androgen receptor promoter Mol Cell Endocrinol 119: 83-93
72. Bentvelsen F, McPhaul MJ, Wilson CM, Wilson JD, George FW 1996 Regulation of immunoreactive androgen receptor in the adrenal gland of the adult rat Endocrinology 137: 2659-2663.
73. Wilson CM, McPhaul MJ 1996 A and B forms of the androgen receptor are expresssed in a variety of human tissues Mol Cell Endocrinol 120: 51-57.
74. Gao TS, Marcelli M, McPhaul MJ 1996 Transcriptional activation and transient expression of the human androgen receptor J Steroid Biochem Mol Biol 59: 9-20.
75. McPhaul MJ, Schweikert H-U, Allman 1997 DR Assessment of androgen receptor function in genital skin fibroblasts using a recombinant adenovirus to deliver an androgen-responsive reporter gene, J Clin Endo Metab, 1944-1948.
76. Young M, Lephart EL, and McPhaul MJ 1997 Expression of aromatase cytochrome P450 in rat H540 Leydig tumor cells J Steroid Biochem Mol Biol 63: 37-44.
77. Shet MS, McPhaul MJ, Fisher CW, Stallings NR, and Estabrook RW 1997 Metabolism of the antiandrogenic drug (flutamide) by human P450 1A2, Drug Metab Disposition 61: 341-348.
78. Jorcyk CL, Liu M-L, Shibata M-A, Maroulakou IG, Komschlies KL, McPhaul MJ, Resau JH , Green JE 1998 Development and characterization of a mouse prostate adenocarcinoma cell line: ductal formation determined by extracellular matrix, Prostate 34: 10-22.
79. Butler R, Leigh PN, McPhaul MJ, and Gallo J-M 1998 Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy Hum Mol Genetics, 7: 121-127.
80. Gao TS, McPhaul MJ 1998 Functional activities of the A- and B- forms of the human androgen receptor in response to androgen receptor agonists and antagonists, Mol Endo 12: 654-663.
81. Avila DM, Fuqua SAW, George FW, McPhaul MJ 1998 Identification of genes expressed in the rat prostate that are modulated differently by castration and Finasteride treatment, J Endocrinology, in press.
82. McPhaul MJ 1998 Male Reproductive Tract Biology in Reproductive and Developmental Toxicology, Korach KS, ed., Marcel Dekker, Inc, New York.
83. McPhaul MJ 1998 Regulation of Reproduction, in Principals of Molecular Medicine, Jameson, JL, ed., Humana Press.
84. McPhaul MJ 1998 Defects of Androgen Action, in Principals of Molecular Medicine, Jameson, JL, ed., Humana Press.
85. Brantley K, Gao T, McPhaul MJ 1998 Genetic Alterations of Androgen Receptor Function, in Hormone Resistance Syndromes, Jameson, JL, ed., Humana Press, in press.
86. McPhaul MJ 1998 Molecular Defects of the Androgen Receptor J Steroid Biochem Mol Biol, in press.
87. Young M, McPhaul MJ 1998 An SF-1 binding site and CRE-like elements are required for the activity of the rat aromatase promoter in rat Leydig tumor cell lines Endocrinology 139: 5082-5093.
88. McPhaul MJ 1999 Molecular Defects of the Androgen Receptor J Steroid Biochem Mol Biol, 69: 315-322.
89. McPhaul MJ 1999 The androgen receptor in syndromes of androgen insensitivity and in prostate cancer, in Gene Engineering and Molecular Models in Endocrinology, Shupnick, MA, ed., Humana Press, in press.
90. Gao TS, Brantley K, Bolu E, McPhaul MJ 1999 RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays Mol Endo 13: 1645-1656.
91. McPhaul MJ, Griffin JE 1999 Male pseudohermaphroditism caused by mutations of the human androgen receptor J Clin Endo Metab 84: 3435-3441.
92. McPhaul MJ 2000 Mutations that alter androgen receptor function, in Endocrinology, DeGroot, L. Ed., in press.
93. Zoppi S, Young M, McPhaul MJ Regulation of Gene Expression by the Nuclear Receptor Family in Genetics of Steroid Biosynthesis and Function, JI Mason, ed., Harwood Academic Publishers, in press.
94. Lanzino M, Catalano S, Genissel C, Ando S, Carreau S, Hamra K, McPhaul MJ Aromatase mRNA is derived from the Proximal Promoter of the Aromatase Gene in Leydig, Sertoli, and Germ cells of the Rat Testes, in press, Biol Reprod.
95. Avila DM, Zoppi S, McPhaul MJ The Androgen Receptor (AR) In Syndromes of Androgen Insensitivity and In Prostate Cancer, Receptor J Steroid Biochem Mol Biol., in press.
96. Zoppi S, Allman Diane R, Gerard R, McPhaul MJ The Expression of the Human Androgen Receptor in Eukaryotic Cells Using a Recombinant Adenovirus Vector Yields High Levels of the Soluble, Functional Receptor Protein, submitted J Mol Endocrinol.
97. Reutens AT, Fu M, Wang C, Albanese C, Zahler M, McPhaul MJ, Sun Z, Balk SP, Janne OA, Palvimo JJ, Pestell RG Prostate Cancer Androgen Receptor Mutations Evade Cyclin D1 Repression, Mol Endo, in press.
98. Maiti S, Meistrich ML, Wilson G, Shetty G, Marcelli M, McPhaul MJ, Morris PL, Wilkinson MF Irradiation Selectively Inhibits Expression from the Androgen-Dependent Pem Homeobox Gene Promoter in Sertoli Cells, Endocrinology, in press.
99. Griffin JE, McPhaul MJ, Russell DW, Wilson JD 2001 The androgen resistance syndromes: Steroid 5a-reductase 2 deficiency, testicular feminization, and related disorders. In: Scriver CR, Beaudet AL, Valle D, Sly WS (eds.), The Metabolic and Molecular Bases of Inherited Disease, 8th ed., McGraw-Hill, New York, Vol. III, Chap. 160, pp 4117-4146.
100. McPhaul MJ, Young M 2001 Complexities of Androgen Action J Amer Acad Derm 45: S87-94.
101. Andriani F, Nan B, Ju Y, Li X, Weigel NL, McPhaul MJ, Kasper S, Kagawa S, Fang B, Matusik RJ, Denner L, Marcelli M 2001 Third generation probasin promoter ARR2PB drives Bax overexpression and apoptosis in androgen receptor positive prostate cancer cells in a dihydrotestosterone-dependent way J Natl Cancer Institute 93: 1314-24.
102. Zoppi S, Young M, McPhaul MJ 2002 Regulation of Gene Expression by the Nuclear Receptor Family in Genetics of Steroid Biosynthesis and Function, JI Mason, ed., Harwood Academic Publisher, Chapter 14 pp 376-403.
103. Avila DM, Wilson CM, Nandi N, Griffin JE, Wilson JD, McPhaul MJ 2002 Immunoreactive Androgen Receptor (AR) In Genital Skin Fibroblasts from Subjects with Androgen Resistance and Undetectable Levels of AR in Ligand Binding Assays, J Clin Endocrinol Metab 87: 182-188.
104. McPhaul MJ 2002 Mutations of the human androgen receptor that cause androgen insensitivity, Recent Progress in Hormone Research 57:181-194.
105. Catalano S, Avila DM, Wilson JD, Glickman SE, McPhaul MJ 2002 Virilization
of the female spotted hyena cannot be explained by alterations in the amino
acid sequence of the androgen receptor (AR) Mol Cell Endocrinol 194: 85-94.
Although my practice includes a range of patients, I have a particular interest in the diagnosis and treatment of patients with disorders of the pituitary and hypothalamus, such as those caused by pituitary adenomas. I work closely with the faculty of the Neurosurgery Department at UT Southwestern to organize preoperative evaluations and post operative care.
My clinical affiliations permit my patients to be seen at Parkland Hospital, Zale-Lipshy Hospital, or the James W. Aston Outpatient Clinic. Information regarding appointments can be obtained through the Endocrine Division patient line at 214-648-4523.
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