NIDA Program Project Grant on Drug Addiction at UT Southwestern

Selected Publications from the PPG

Barrot M, Olivier JDA, Perrotti LI, Impey S, Storm DR, Neve RL, Zachariou V, Nestler EJ (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci USA 99:11435-11440.

Barrot M, Wallace-Black D, Bolanos CA, Graham D, Perrotti LI, Neve RL, Chambliss H, Yin JC, Nestler EJ (2005) Regulation of anxiety and initiation of sexual anxiety by CREB in the nucleus accumbens. Proc Natl Acad Sci USA 102:8357-8362.

Choi K-H, Whisler K, Graham D, Self DW (2006) Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience 137:373-383.

Colby CR, Whisler K, Steffen C, Nestler EJ, Self DW (2003) ∆FosB enhances incentive for cocaine. J Neurosci 23:2488-2493.

Dong Y, Green T, Saal D, Marie H, Neve R, Nestler EJ, Malenka RC (2006) CREB modulates excitability of nucleus accumbens neurons. Nature Neurosci 9:475-477.

Edwards S, Graham DL, Bachtell RK, Self DW (2007) Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Eur J Neurosci 25:2201-2213.

Green TA, Alibhai IN, Hommel JD, DiLeone RJ, Kumar A, Theobald DE, Neve RL, Nestler EJ (2006) Induction of ICER expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci 26:8235-8242.

Han M-H, Bolanos CA, Green TA, Olson VG, Neve RL, Liu R-J, Aghajanian GK, Nestler EJ (2006) Role of cAMP response element-binding protein (CREB) in the rat locus coeruleus: Regulation of neuronal activity and opiate withdrawal behaviors. J Neurosci 26:4624-4629.

Kreitzer AC, Malenka RC (2007) Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models. Nature 445:643-647.

Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N.M., Theobald, D.E.H., Truong, H.-T., Russo, S.J., LaPlant, Q., Sasaki, T.S., Whistler, K.N., Neve, R.L., Self, D.W., and Nestler, E.J. (2005) Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron 48:303-314.

McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and ∆FosB. Nature Neurosci 11:1208-1215.

McClung CA, Nestler EJ, Zachariou V (2005) Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J Neurosci 25:6005-6015.

Olausson P, Jentsch JD, Tronson N, Neve R, Nestler EJ, Taylor JR (2006) ∆FosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci 26:9196-9204.

Olson VG, Zabetian CP, Bolanos CA, Edwards S, Barrot M, Eisch AJ, Hughes T, Self DW, Neve RL, Nestler EJ (2005) Regulation of drug reward by CREB: Evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci 25:5553-5562.

Saal D, Dong Y, Bonci A, Malenka RC (2003) Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37:577-582.

Sutton MA, Schmidt EF, Choi K-H, Schad CA, Whisler K, Simmons D, Karanian DA, Monteggia LM, Neve RL, Self DW (2003) Extinction-Induced Plasticity in AMPA Receptors Reduces Cocaine-Seeking Behavior. Nature 421:70-75.

Taylor JR, Lynch WJ, Sanchez H, Olausson P, Nestler EJ, Bibb, JA (2007) Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor activating and incentive motivational effects of cocaine. Proc Natl Acad Sci USA 104:4147-4152.

Todtenkopf MS, Marcus JF, Portoghese PS, Carlezon WA Jr (2004) Effects of kappa opioid ligands on intracranial self-stimulation in rats. Psychopharmacology 172: 463-470.

Todtenkopf MS, Parsegian A, Naydenov A, Neve RL, Konradi C, Carlezon WA Jr (2006) Brain reward regulated by AMPA receptor subunits in the nucleus accumbens shell. J Neurosci 26:11665-11669.

Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, DiLeone RJ, Kumar A, Nestler EJ (2006) ∆FosB: An essential role for ∆FosB in the nucleus accumbens in morphine action. Nature Neurosci 9:205-211.