Previously,
Dr. Grundy had been a Professor of Medicine at the University
of California, San Diego and Chief of the Metabolic Division
at the San Diego VA Medical Center. Before that, he was director
of the National Institutes of Health Phoenix Clinical Research
Unit, and Assistant Professor at Rockefeller University, New
York City, and Baylor College of Medicine, Houston, Texas.
Education
Dr.
Grundy received his B.S. at Texas Tech College, Lubbock Texas,
MD and MS at Baylor College of Medicine, Houston, and Ph.D.
at Rockefeller University, New York City. He did residency
training in Internal Medicine at Baylor College of Medicine
and at New York Hospital, New York City.
Research Accomplishments
Dr.
Grundy's major research area is in cholesterol and lipoprotein
metabolism. He has published over 300 original papers, and
numerous solicited articles and chapters. Notable research
accomplishments include the development of methods for measuring
cholesterol balance and biliary lipid secretion in humans,
identifying the metabolic causes of cholesterol gallstones,
defining effects of saturated and unsaturated fats, especially
monounsaturated fatty acids, on cholesterol and lipoprotein
metabolism, uncovering genetic defects underlying hypercholesterolemia
and other forms of dyslipidemia, identifying metabolic defects
in hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
and defining mechanisms of action of several lipid-lowering
drugs, notably fibrates and HMG CoA reductase inhibitors (statins).
Role in the Center for Human Nutrition
Dr.
Grundy has played significant roles in development of public
policy on the prevention of cardiovascular disease. This work
has been carried out through the American Heart Association,
the National Cholesterol Education Program, the National Academies
Institute of Medicine, and the U.S. Government. He has been
chair of a number committees of the American Heart Association
were he has assisted in the development of position statements
on nutrition, treatment of hyperlipidemia, primary prevention
and secondary prevention of coronary heart disease, risk assessment,
and diabetes and cardiovascular disease. Dr. Grundy is the
American Heart Association's representative to the US National
Cholesterol Education Program (NCEP). In this role he has
assisted in the development of "cholesterol policy" including
three reports of the Expert Panel on Detection, Evaluation,
and Treatment of High Blood Cholesterol in Adults; in the
second report he was chair of the panel, and he also is chair
of the panel that is producing the third report. He also was
a member of the NCEP panel that produced public health guidelines.
He served on the committee that wrote the Dietary Guidelines
for Americans 2000. In the Institute of Medicine, he has served
on the Food and Nutrition Board (FNB); and he is a member
of the standing FNB committee on Dietary Reference Intakes
(DRI); and he currently is a member of the panel developing
DRIs for macronutrients.
Professional
Societies, Awards and Achievements
Dr. Grundy is a member
of the American Society for Clinical Investigation, the American
Association of Physicians, and the National Academies Institutes
of Medicine. He received The Merit Award from The American
Heart Association in 1983. He gave the Lydia J. Roberts Memorial
Lecture in Chicago in 1988 and the American Heart Association's
George Lyman Duff Lecture in 1990. In 1990, he was awarded
an honorary degree in medicine from the University of Helsinki,
Finland. In 1994, he received the Roger J. Williams Award
in Preventive Nutrition. He was made a member of the Institute
of Medicine in 1996, in 1997 he received the Bristol Myers
Squibb Award for Distinguished Achievement in Nutrition Research,
and in 1998, the American Society for Clinical Nutrition's
E.V. McCollum award. In 2000, he became President Elect of
the International Atherosclerosis Society.
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