We are investigating the molecular mechanisms of lipodystrophies for both the genetic and acquired varieties. Opportunities are available to study the mechanism involved, which cause lipodystrophies, by recently identified genes. This includes creating knock-out and transgenic mice models, modification at the cellular levels and the biochemistry behind such defects. Because of the genetic heterogeneity of the lipodystrophies, identification of additional genes will become necessary using positional cloning approaches. The lab is well equipped to carry out such experiments. This includes, ABI-377 and ABI 7700, cell culture equipment and imaging systems. In addition, we utilise UT Southwestern's several core laboratories which include DNA sequencing, molecular imaging, transgenic as well as micro array facilities.