Anoop Misra, MD

UT Southwestern Appointment

Anoop Misra, MD, is a visiting assistant professor in Internal Medicine, Division of Nutrition and Metabolic Diseases.

Medical Education and Appointments

Dr Misra attended medical school and did his residency at the All India Institute of Medical Sciences (AIIMS), New Delhi, India. Later he joined department of Internal Medicine at AIIMS as faculty. From a junior faculty member in 1991, he attained rank of Professor of Internal Medicine at AIIMS in 2000.

Research Interests

The focus of Dr Misra’s research has been on obesity, lipodystrophies, metabolic syndrome (insulin resistance syndrome), type 2 diabetes mellitus, hyperlipidemia and other cardiovascular risk factors.

As a faculty member at AIIMS, New Delhi, he showed high prevalence of diabetes mellitus, dyslipidemia and metabolic syndrome in the underprivileged population living in urban resettlement colonies. Other previously unreported observations on the same population included high prevalence of hyperhomocysteinemia and endothelial dysfunction (marker: soluble intercellular adhesion molecule-1). Further, high prevalence of generalized and abdominal obesity associated with high C-reactive protein levels have been shown by his group in adolescent and young adult population in New Delhi.

As a World Health Organization fellow in 1996, he worked at the Center of Human Nutrition. During this time, he showed strong relationship of subcutaneous abdominal fat, particularly in the posterior abdominal region, with insulin sensitivity. Subsequently, in New Delhi, working on body composition of Asian Indians, he showed that current limits of body mass index and waist circumference are not appropriate for the diagnosis of obesity in Asian Indians based on the body composition data and prevalence of cardiovascular risk factors.

Other significant researches include correlation of intramyocellular triglyceride (IMCL) content of soleus muscle with insulin resistance in Asian Indians and use of simvastatin in the management of diabetic retinopathy. Dr Misra has also shown that young type 2 diabetics and young hyperlipidemic Asian Indians have cognitive dysfunction, and latter have early abnormalities in cerebral blood glow. In a collaborative research with Indian Institute of Technology, New Delhi, his group contributed in the development of new laboratory marker for the evaluation of long-term glycemia in patients with diabetes mellitus.

Presently he is working on the clinical profile and pathophysiological correlations in acquired generalized lipodystrophies and lipodystrophy in HIV-infected subjects.

Selected Articles

Misra A, Garg A.
Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature.
Medicine (in press)

Chen D, Misra A, Garg A.
Lipodystrophy in human immunodeficiency virus-infected patients.
J Clin Endocrinol Metab. 2002 Nov;87(11):4845-56.

Garg A, Misra A.
Insulin resistance, liver steatosis, and adipose tissue disorders (Editorial).
J Clin Endocrinol Metab 2002; 87(7): 3019-22

Garg A, Misra A.
Lipodystrophies and diabetes.
In: International Textbook of Diabetes Mellitus. Defronzo RA (Eds). John Wiley. Sussex, London, Toronto, New York. 2003 (in press)

Sethi A, Misra A, Pandey RM, Luthra K, Rama Devi J, Sharma R, Khanna N, Dwivedi M. Soluble inter-cellular adhesion molecule-1 in urban Asian north Indian population: relationship with anthropometric and metabolic covariates.
Disease Markers (In press).

Misra A, Athiko D, Sharma R, Pandey RM, Khanna N.
Non-obese hyperlipidemic Asian northern Indian males have adverse anthropometric profile.
Nutr Metab Cardiovasc Dis (In press).

Misra A.
We need ethnic-specific criteria for classification of BMI.
In: Progress in Obesity Research: 9. (Eds: Medeiros-Neto G, Halpern, A) 2003 (In press).

Misra A, Sinha S, Kumar M, Jagannathan NR, Pandey RM.
Proton magnetic resonance spectroscopy study of soleus muscle in non-obese healthy and type 2 diabetic Asian Northern Indian males: High intramyocellular lipid content correlates with excess body fat and abdominal obesity.
Diabetic Medicine (in press).

Bijukumar G, Vigneshwaran N, Karmakar N, Anand S, Misra A.
Evaluation of auto fluorescent property of Hb-AGE as a long-term glycemic index of diabetes mellitus.
Diabetes (in press).

Vikram NK, Pandey RM, Dharma S, Misra A.
Hyperhomocysteinemia in healthy Asian Indians (letter).
Am J Hematol 2002 (in press)

Misra A.
Overnutrition and nutritional deficiency contribute to metabolic syndrome and atherosclerosis in Asian Indians (letter).
Nutrition 2002; 18(7-8): 702-3

Sethi A, Misra A, Pandey RM, Luthra K, Rama Devi J, Sharma R, Khanna N, Dwivedi M.
Soluble inter-cellular adhesion molecule-1 in urban Asian north Indian population: relationship with anthropometric and metabolic covariates. Disease Markers 2002; 18: 111-120

Vikram NK, Misra A.
Non-obese (BMI<25 kg/m2) Asian Indians with ‘normal’ waist circumference have high cardiovascular risk.
Nutrition 2002. (In press)

Misra A, Athiko D, Sharma R, Pandey RM, Khanna N.
Non-obese hyperlipidemic Asian northern Indian males have adverse anthropometric profile.
Nutr Metab Cardiovasc Dis 2002; 12(4): 178-83.

Misra A, Vikram NK. Insulin Resistance Syndrome
(Metabolic Syndrome) and Asian Indians (Review).
Curr Sci 2002; 83(12): 1483-1496

Misra A, Vikram NK, Pandey RM, Dwivedi M, Ahmad FU, Luthra K, Jain K, Khanna N, Devi JR, Sharma R, Guleria R.
Hyperhomocysteinemia, and low intakes of folic acid and vitamin B12 in urban North India.
Eur J Nutr. 2002 Apr;41(2):68-77.

Luthra K, Bharghav B, Chabbra S, Das N, Misra A, Agarwal DP, Pandey RM, Srivastava LM.
Apolipoprotein E polymorphisms in Northern Indian patients with coronary heart disease: phenotype distribution and relation to serum lipids and lipoproteins.
Mol Cell Biochem 2002; 232(1-2): 97-102

Misra A, Chaudhary D, Vikram NK, Mittal V, Rama Devi J, Pandey RM, Khanna N, Sharma R, Peshin S.
Insulin resistance and clustering of atherogenic risk factors in women belonging to low socio-economic strata in urban slums of North India.
Diabetes Res Clin Pract 2002; 56(1): 73-5

Misra A, Pandey RM, Sharma R.
Non-communicable diseases (Diabetes mellitus, obesity, hypertension and dyslipidemia) in urban slums (letter).
Natl Med J Ind 2002; 15(4): 242-4.

Misra A, Pandey RM, Devi JR, Sharma R, Vikram NK, Khanna N.
High prevalence of diabetes, obesity and dyslipidaemia in urban slum population in northern India.
Int J Obes Relat Metab Disord. 2001 Nov;25(11):1722-9.

Misra A, Sharma R, Pandey RM, Khanna N.
Adverse profile of dietary nutrients, anthropometry and lipids in urban slum dwellers of northern India.
Eur J Clin Nutr. 2001 Sep;55(9):727-34.

Dudeja V, Misra A, Pandey RM, Devina G, Kumar G, Vikram NK.
BMI does not accurately predict overweight in Asian Indians in northern India.
Br J Nutr. 2001 Jul;86(1):105-12.

Misra A, Arora A, Mondal S, Pandey RM, Jailkhani B, Peshin S, Chaudhury D, Saluja T, Singh P, Chandra S, Luthra K, Vikram NK.
Relation between plasma leptin and anthropometric and metabolic covariates in lean and obese diabetic and hyperlipidemic Asian Northern Indian subjects.
Diab Nutr Metab 2001; 14(1): 18-26.

Sen K, Misra A, Kumar A, Pandey RM.
Simvastatin retards progression of diabetic retinopathy in type 2 diabetic patients with hyperlipidemia.
Diab Res Clin Pract 2002; 56(1): 1-11.

Misra A, Nishanth S, Pasha ST, Pandey RM, Sethi P, Rawat DS. Relationship of XbaI and EcoRI polymorphisms of apolipoprotein-B gene to dyslipidemia and obesity in Asian Indians in northern India.
Ind Heart J 2001; 53: 177-183.

Misra A.
Risk factors for atherosclerosis in young individuals. (Review).
J Cardiovasc Risk 2000; 7(3): 215-29.

Misra A, Shukla P, Reddy KS, Lall SB, Peshin SS, Pandey RM. Serum insulin levels in non-obese, non-diabetic Asian Indians with acute coronary and non-coronary events.
Ind Heart J 2000; 52(3): 280-4.

Misra A.
Insulin resistance syndrome: current perspective and its relevance in Indians. (Review).
Ind Heart J 1999; 50(4): 385-395.

Misra A, Raghu C, Reddy KS, Mohan A, Bajaj JS.
Hyperinsulinemia and dyslipidemia in non-obese normotensive children of hypertensive patients in Northern India.
Blood Pressure 1999; 8: 1-5.

Misra A, Mittal V, Jain S, Bajaj JS.
Correlation of acetylator phenotype with peripheral, autonomic and central neuropathy in NIDDM patients.
Eur J Clin Pharmacol 1999; 55(6): 419-424.

Misra A, Reddy B, Reddy KS, Mohan A, Bajaj JS.
Clustering of impaired glucose tolerance, hyperinsulinemia and dyslipidemia in young North Indian patients with coronary artery disease.
Ind Heart J 1999; 51(3): 275-280.

Misra A, Kathpalia R, Roy NK, Lall SB, Peshin S.
Hyperinsulinemia in non-obese, non-diabetic subjects with isolated systolic hypertension.
Ind Heart J 1998; 50: 49-54.

Dey J, Misra A, Desai NG.
Cognitive function in younger non-insulin dependent diabetic patients.
Diabetes Care 1997; 20(1): 32-35.

Misra A, Garg A, Abate N, Peshock RM, Stray-Gundersen J, Grundy SM.
Subcutaneous anterior and posterior abdominal adipose tissue mass and its relation to insulin sensitivity.
Obes Res 1997; 5: 93-99

Misra A, Garg A.
Obesity, leptin and its receptor.
J Invest Med 1996; 44: 540-48.