Colleen A. McClung, Ph.D. EDUCATION 2001-2003 - Postdoctoral fellowship, University of Texas Southwestern Medical Center, Dallas, Texas 1995-2001 - Ph.D. Biology, University of Virginia, Charlottesville, Virginia 1996 - Neurobiology of Drosophila Course, Cold Spring Harbor Laboratories, Cold Spring Harbor, New York 1990-1994 - B.S. Biology, Minor Chemistry, University of North Carolina, Chapel Hill, North Carolina RESEARCH EXPERIENCE 2005-present Assistant Professor, University of Texas, Southwestern Medical Center, Dallas, Texas Department of Psychiatry Title of research: "Role of circadian genes in psychiatric disorders" 2003-2005 Assistant Instructor, University of Texas, Southwestern Medical Center, Dallas, Texas Department of Psychiatry Title of research: "Role of circadian genes in psychiatric disorders" 2001-2003 Postdoctoral Research, University of Texas, Southwestern Medical Center, Dallas, Texas Advisor: Dr. Eric J. Nestler Title of research: “The molecular mechanisms of ΔFosB and CREB, and the regulation of drug reward” 1995-2001 Ph.D. Thesis, University of Virginia, Charlottesville, Virginia Advisor: Dr. Jay Hirsh Title of research: “A role for tyramine in the development of sensitization to cocaine in Drosophila melanogaster” 1994-1995 Laboratory Technician, University of North Carolina, Chapel Hill, North Carolina Advisors: Dr. Dana Fowlkes, and Dr. Brian Kay Title of Research: “The discovery and characterization of novel DNA binding peptides that interact with transcriptional regulatory sites using bacterial phage display” 1992-1994 Undergraduate Research, University of North Carolina, Chapel Hill, North Carolina Advisor: Dr. Brian Kay Title of Research: “The regulation of α-5 and β-1 integrins in Xenopus oocytes” 1991-1994 Laboratory Assistant, University of North Carolina, Chapel Hill, North Carolina Advisor: Dr. Lillie Searles TEACHING EXPERIENCE 2004-present STARS program volunteer lecturer, University of Texas Southwestern Medical Center, Dallas, TX 2003-present Advanced Neuroscience Course for Psychiatry Residents, Lecturer, University of Texas Southwestern Medical Center, Dallas TX 1996 Introductory Cell Biology Laboratory for Undergraduates, Teaching Assistant, University of Virginia, Charlottesville, VA AWARDS AND POSITIONS McKnight Neuroscience of Brain Disorders Award (2008-2011) NIH Exporatory/Developmental Research Grant Award (R21) (2007-2009) NARSAD Young Investigator Award (2007-2009) President’s Research Council Distinguished Young Investigator Award (2007-2008) Blue Gator Research Award (2007) 2005-2010 NIH/NIDA Mentored Research Scientist Development Award (K01), University of Texas Southwestern Medical Center 2005-2008 NARSAD Young Investigator Award, University of Texas Southwestern Medical Center 2005 The Music Festival for Mental Health Award, University of Texas Southwestern Medical Center 2002-2003 NIH/NIDA Postdoctoral Training Grant, University of Texas Southwestern Medical Center 1998-2001 NIH/NIDA National Research Service Award for Predoctoral Fellows, University of Virginia 1998-1999 Graduate Student/Postdoctoral Association President, University of Virginia 1998 British Petroleum Outstanding Graduate Student Award, University of Virginia 1991-1992 RJ Reynolds Science Scholarship, University of North Carolina 1991 Phi Eta Sigma National Honor Society, University of North Carolina 1990-1991 NOMDA Nationwide Scholarship, University of North Carolina 1990 Bausch and Lomb Science Award, North Carolina PROFESSIONAL AFFILIATIONS 1999-present Society for Neuroscience 1997-present American Association for the Advancement of Science PUBLICATIONS Wallace, D.L., Graham, D.L., Han, M-H., Green, T.A., Vialou, V., Chakravarty, S., Kumar, A., Krishnan, V., Neve, R., Cooper, D.C., Barrot, M., McClung, C.A., and Nestler, E.J. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Submitted. Lutter, M., Krishnan, V., Russo, S.J., McClung, C.A., and Nestler, E.J. Orexin Mediates Behavioral Adaptations to Calorie Restriction. Submitted. Peevey, J., Falcon, E., Roybal, K., Phillips, C., Sasaki, T., Kumar, A., Barrot, M., and McClung, C.A. Differential regulation of circadian genes in striatal regions by cocaine, and their role in drug reward. Submitted. Roybal, K., Theobold, D., DiNieri, J.A., Graham, A., Russo, S., Krishnan, V., Kumar, A., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M.H., Orsulak, P., Takahashi, J.S., Nestler, E.J., Carlezon, W.A. Jr., McClung, C.A. Mania-like behavior induced by disruption of CLOCK.(2007) Mania-like behavior induced by disruption of CLOCK. Proc. Natl. Acad. Sci. USA 104(15): 6406-6411. Berton, O., McClung, C.A., Dileone, R.J., Krishnan, V., Russo, S., Graham, D., Tsankova, N., Bolanos, C.A., Rios, M., Monteggia, L.M., Self, D.W., and Nestler, E.J. (2006) Essential role of BDNF in dopaminergic reward regions in social defeat stress. Science 311: 864-868. McClung C.A., Nestler E.J., and Zachariou V. (2005) Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. Journal of Neuroscience 25(25): 6005-6015. McClung C.A., Sidiropoulou K., Vitaterna M., Takahashi J.S., White F.J., Cooper D.C. and Nestler E.J. (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci USA 102 (26): 9377-9381. Cole S.H., Carney G.E., McClung C.A., Willard S.S., Taylor B.J. and Hirsh J. (2005) Two functional but non-complementing Drosophila tyrosine decarboxylase genes: a role for regulating neural octopamine in female fertility. Journal of Biological Chemistry 280 (15): 14948-14955. Gong Z., Son W., Chung, Y.D., Kim J., Shin D.W., McClung C.A., Lee Y. Lee H.W., Chang D.J., Kaang B.K., Cho, H., Oh, U., Hirsh J., Kernan M.J., KimC. (2004) The interdependent TRPV channel subunits inactive and nanchung mediate hearing in Drosophila. Journal of Neuroscience 24(41): 9059-9066. McClung C.A. and Nestler E.J. (2003) Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nature Neuroscience 6(11): 1208-1215. McClung C.A. and Hirsh J. (1999) The trace amine, tyramine, is essential for sensitization to cocaine in Drosophila. Current Biology 9: 853-860. (cover) McClung C.A. and Hirsh J. (1998) Stereotypic behavioral responses to cocaine and the development of sensitization in Drosophila melanogaster. Current Biology 8 (2), 109-112. (cover) Book Chapters and Reviews: Russo, S.J. and McClung C.A. The biology of drug addiction. Neuroscience in Medicine, chapter 33, 3rd ed. Humana Press, New Jersey. In press. McClung, C.A. A role for the Clock gene in bipolar disorder. Cold Spring Harbor Symposia on Quantitative Biology: Clocks and Rhythms, Volume 72. In press. McClung, C.A. and Nestler, E.J. (2008) Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33: 3-17. McClung, C.A. (2007) Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction. The Scientific World Journal 7: 194-202. McClung, C.A. (2007) Circadian genes, rhythms, and the biology of mood disorders. Pharmacology & Therapeutics. 114: 222-232. McClung, C.A. (2007) Clock genes and bipolar disorder: implications for therapy. Pharmacogenomics 8: 1097-1100. McClung, C.A. (2006) The molecular mechanisms of morphine addiction. Reviews in the Neurosciences. 17:393-402. McClung, C.A. and Nestler, E.J. (2005) Stimulus dependent regulation of gene expression in the central nervous system. Databasing the Brain: From Data to Knowledge, Chapter 11, 1st ed. John Wiley and Sons, New York. McClung, C.A., Ulery, P.G., Perrotti, L.I., Zachariou, V., Berton, O., and Nestler, E.J. (2004) ΔFosB: A molecular switch for long-term adaptations in the brain. Molecular Brain Research. 132:146-154.